l-Proline as a Valuable Scaffold for the Synthesis of Novel Enantiopure Neonicotinoids Analogs.

In this research, six neonicotinoid analogs derived from l-proline were synthesized, characterized, and evaluated as insecticides against . Most of the target compounds showed good to excellent insecticidal activity. To the best of our knowledge, this is the first report dealing with the use of enantiopure l-proline to get neonicotinoids. These results highlighted the compound as an excellent candidate used as the lead chiral insecticide for future development. Additionally, molecular docking with the receptor and compound was carried out to gain insight into its high activity when compared to dinotefuran. Finally, the neurotoxic evaluation of compound showed lower toxicity than the classic neonicotinoid dinotefuran.