Randall G C
Agriculture Canada, Animal Diseases Research Institute, Nepean, Ontario.
J Dev Physiol. 1988 Feb;10(1):77-83.
The role of cortisol as a factor controlling the deposition of glycogen in the pig fetus was examined by infusing either a low dose (1 mg/day) or a high dose (3 mg/day) of cortisol into chronically-catheterized hypophysectomized fetal pigs for five days beginning on day 100-104 of gestation. After infusion, liver glycogen was significantly higher (P less than 0.05) and lung glycogen significantly lower (P less than 0.05) than in uninfused hypophysectomized litter mates although concentrations were significantly different from intact litter mates (P less than 0.05). Although skeletal and cardiac muscle content increased after infusion this difference was not significant. Changes in tissue glycogen content were similar for both the low and high rates of infusion. These observations indicate that exogenous cortisol alone is able to stimulate liver glycogen deposition and reverse the effect of hypophysectomy. Although other factors may be necessary for maximal response this suggests that cortisol is an important stimulant for liver glycogen deposition in the fetal pig. The effect of cortisol on muscle glycogen was equivocal suggesting that other hormones may play a more important role in this tissue.
通过从妊娠第100 - 104天开始，对经长期插管的垂体切除胎儿猪连续五天输注低剂量（1毫克/天）或高剂量（3毫克/天）的皮质醇，研究了皮质醇作为控制猪胎儿糖原沉积因素的作用。输注后，与未输注的垂体切除同窝仔猪相比，肝脏糖原显著升高（P小于0.05），肺糖原显著降低（P小于0.05），尽管其浓度与完整同窝仔猪有显著差异（P小于0.05）。虽然输注后骨骼肌和心肌含量增加，但这种差异不显著。低剂量和高剂量输注时组织糖原含量的变化相似。这些观察结果表明，单独的外源性皮质醇能够刺激肝脏糖原沉积并逆转垂体切除的影响。尽管最大反应可能需要其他因素，但这表明皮质醇是胎儿猪肝糖原沉积的重要刺激物。皮质醇对肌肉糖原的影响不明确，这表明其他激素可能在该组织中起更重要的作用。
