软组织肉瘤脑转移患者的临床转归。

Clinical Outcome of the Patients With Brain Metastasis from Soft Tissue Sarcomas.

机构信息

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;

出版信息

Anticancer Res. 2021 Feb;41(2):1027-1034. doi: 10.21873/anticanres.14858.

DOI:10.21873/anticanres.14858

PMID:33517311

Abstract

BACKGROUND/AIM: This study aimed to evaluate the association of clinical characteristics with treatment outcomes to ascertain the appropriate treatment options for soft tissue sarcomas (STS) patients with brain metastasis (BM).

PATIENTS AND METHODS

Medical records of STS patients with BM who were treated in our institutions were retrospectively reviewed, and analyzed to identify the factors associated with post-BM survival.

RESULTS

Among the 509 STS patients, BM occurred in five patients (0.98%). The median survival after BM was 1.5 months. Histological subtypes of the primary lesions in the five BM patients were: two synovial sarcomas, one myxoid liposarcoma, one alveolar soft part sarcoma, and one rhabdomyosarcoma. Among the five BM patients, the post-BM survival of two patients, who underwent surgery and postoperative radiotherapy, was longer than that of the other patients (p<0.01).

CONCLUSION

Combined surgery and postoperative radiotherapy effectively managed symptoms and prolonged survival in STS patients with BM.

摘要

背景/目的：本研究旨在评估临床特征与治疗结果的关系，以确定软组织肉瘤（STS）伴脑转移（BM）患者的合适治疗选择。

患者与方法

回顾性分析了在我院治疗的伴有 BM 的 STS 患者的病历，并对其进行分析以确定与 BM 后生存相关的因素。

结果

在 509 例 STS 患者中，有 5 例（0.98%）发生 BM。BM 后中位生存时间为 1.5 个月。5 例 BM 患者的原发灶组织学亚型为：滑膜肉瘤 2 例，黏液样脂肪肉瘤 1 例，腺泡状软组织肉瘤 1 例，横纹肌肉瘤 1 例。在 5 例 BM 患者中，接受手术和术后放疗的 2 例患者的 BM 后生存时间长于其他患者（p<0.01）。