Sigalla Jeanne, Duparc Alegria Nathalie, Le Roux Enora, Toumazi Artemis, Thiollier Anne-Françoise, Holvoet Laurent, Benkerrou Malika, Dugue Sophie, Koehl Berengere
Pain Management Unit, Hôpital Robert Debré, APHP, F-75019 Paris, France.
Unité d'Épidémiologie Clinique, Inserm, CIC 1426, Hôpital Universitaire Robert Debré, AP-HP, Nord-Université de Paris, F-75019 Paris, France.
Children (Basel). 2021 Jan 26;8(2):84. doi: 10.3390/children8020084.
The majority of hospitalizations of patients with sickle cell disease (SCD) are related to painful vaso-occlusive crises (VOCs). Although the pain of VOC is classically nociceptive, neuropathic pain (NP) has also been demonstrated in SCD patients. The aim of our study is to specify the prevalence of NP during VOCs in SCD children using a dedicated scale and to measure its characteristics. We performed a prospective study that included SCD children hospitalized for an acute VOC. The presence of NP was sought with the DN4 scale on the second and fourth days of hospitalization. A total of 54 SCD children were included in the study. Overall, 41% of the patients ( = 22) experienced neuropathic pain during the VOC, mostly at an early stage (Day 2). The median age, the sex ratio, the location of the pain, and the morphine consumption were similar for patients with and without NP. Our study shows that neuropathic pain is very common during VOCs in SCD children. The absence of identified risk factors should prompt us to be vigilant regardless of the patient's age, sex, and clinical presentation.
镰状细胞病（SCD）患者的大多数住院情况与疼痛性血管闭塞危象（VOCs）有关。尽管VOC的疼痛传统上是伤害感受性的，但在SCD患者中也已证实存在神经性疼痛（NP）。我们研究的目的是使用专用量表确定SCD儿童在VOC期间NP的患病率，并测量其特征。我们进行了一项前瞻性研究，纳入因急性VOC住院的SCD儿童。在住院的第二天和第四天，使用DN4量表来查找NP的存在情况。该研究共纳入了54名SCD儿童。总体而言，41%的患者（n = 22）在VOC期间经历了神经性疼痛，大多在早期阶段（第2天）。有NP和无NP的患者在年龄中位数、性别比、疼痛部位和吗啡消耗量方面相似。我们的研究表明，神经性疼痛在SCD儿童的VOC期间非常常见。未发现危险因素这一情况应促使我们无论患者年龄、性别和临床表现如何都保持警惕。
