Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Department of Dermatology, Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Dermatol Ther. 2021 Mar;34(2):e14847. doi: 10.1111/dth.14847. Epub 2021 Feb 13.
Beta-2 adrenergic receptors are the only subgroup of beta-adrenergic receptors expressed in the membrane of large cells, including skin keratinocytes, fibroblasts, and melanocytes. Alterations in the function or concentration of β2 adrenoreceptors related to keratinocytes are associated with some skin conditions. Some findings suggest the role of β2 adrenoreceptors in maintaining the function and integrity of the epidermis. Beta-receptor antagonists can be systemically and topically effective in healing hemangioma, paronychia, vasculitis ulcer, tufted angioma, acute and chronic wounds. Most studies with a strong design on this subject deal with the systemic form, but recently, numerous case and group reports and smaller studies have focused on topical forms, especially topical timolol. The present comprehensive review study surveys the role of topical timolol in acute and chronic wound healing in the field of dermatology.
β2 肾上腺素能受体是大细胞膜中表达的唯一β肾上腺素能受体亚群，包括皮肤角质形成细胞、成纤维细胞和黑素细胞。与角质形成细胞相关的β2 肾上腺素能受体功能或浓度的改变与某些皮肤状况有关。一些研究结果表明β2 肾上腺素能受体在维持表皮功能和完整性方面的作用。β-受体拮抗剂在治疗血管瘤、甲旁腺炎、血管炎溃疡、丛状血管瘤、急性和慢性伤口方面具有全身和局部的疗效。大多数关于这一主题的设计严谨的研究都涉及全身形式，但最近，大量的病例和组报告以及较小的研究集中在局部形式，特别是局部噻吗洛尔。本综述研究调查了局部噻吗洛尔在皮肤科急性和慢性伤口愈合中的作用。
