神经管缺陷与中国队列中泌尿生殖系统先天性异常的关联。
Association of neural tube defects with congenital abnormalities of the urogenital system in a Chinese cohort.
机构信息
Department of Pediatric Surgery, Jiaxing Maternity and Child Health Care Hospital, No. 2468, Zhonghuan East Road, Nanhu District, 314051, Jiaxing, China.
Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Jiaxing Branch, Shanghai Jiaotong University, 314051, Jiaxing, China.
出版信息
BMC Pediatr. 2021 Feb 5;21(1):66. doi: 10.1186/s12887-021-02492-8.
BACKGROUND
This study aimed to retrospectively analyze the correlation between congenital abnormality of the urogenital system and various factors in children with neural tube defects (NTDs).
METHODS
A total of 190 children with congenital NTDs, who were admitted to a hospital from May 2013 to May 2018, were included into the present study. All admitted children with congenital NTDs were carried out routine abdominal B-ultrasound examinations to determine the malformations of the abdominal organs, including the urinary system. Children with a B-ultrasound result of suspected and unsure malformation underwent intravenous pyelography (IVP) and voiding cysto-urethrography (VCU), and this was further confirmed by the CT results.
RESULTS
The incidence of urogenital malformation was 12.1% (23/190) in children with congenital NTDs. For the 23 children with urogenital malformations, most of these children had no definite urinary system symptoms, while some of these children had multiple incidences of urinary system infections.
CONCLUSIONS
Congenital NTDs are often combined with urogenital malformations, if not specifically searched these may be overlooked. The early detection of these malformations is beneficial to reduce the risk of operation and improve the prognosis.
背景
本研究旨在回顾性分析儿童神经管缺陷（NTDs）与各种因素之间先天性泌尿生殖系统异常的相关性。
方法
本研究纳入了 2013 年 5 月至 2018 年 5 月期间在我院就诊的 190 例先天性 NTD 患儿。所有先天性 NTD 患儿均进行常规腹部 B 超检查，以确定腹部器官（包括泌尿系统）的畸形。对 B 超结果可疑或不确定的畸形患儿进行静脉肾盂造影（IVP）和排尿性膀胱尿道造影（VCU）检查，进一步通过 CT 结果确诊。
结果
190 例先天性 NTD 患儿中，泌尿生殖系统畸形的发生率为 12.1%（23/190）。在 23 例存在泌尿生殖系统畸形的患儿中，大多数患儿无明确的泌尿系统症状，部分患儿泌尿系统感染反复发作。
结论
先天性 NTDs 常合并泌尿生殖系统畸形，如果不进行专门检查可能会被忽视。早期发现这些畸形有利于降低手术风险，改善预后。
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