神经内分泌肝转移瘤：肝移植的作用
Neuroendocrine liver metastases: The role of liver transplantation.
作者信息
D'Amico Giuseppe, Uso Teresa Diago, Del Prete Luca, Hashimoto Koji, Aucejo Federico N, Fujiki Masato, Eghtesad Bijan, Sasaki Kazunari, David Kwon Choon H, Miller Charles M, Quintini Cristiano
机构信息
Transplantation Center, Department of Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Transplantation Center, Department of Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Transplant Rev (Orlando). 2021 Apr;35(2):100595. doi: 10.1016/j.trre.2021.100595. Epub 2021 Jan 15.
PURPOSE OF REVIEW
Neuroendocrine tumor (NET) metastasis localized to the liver is an accepted indication for liver transplantation as such tumors have a low biological aggressiveness in terms of malignancy and are slow growing.
RECENT FINDINGS
The long-term results are comparable with and in some cases even better than those of transplantations performed for primary liver cancer. However, compared with nonmalignant conditions, neuroendocrine liver metastasis (NELM) may result in an inferior outcome of transplantation. In the face of the scarcity of donated organs and recent improved results of non-surgical treatment for NELM, controversy over patient selection and timing for liver transplantation continues.
SUMMARY
In this review, we provide an overview of the diagnostic work-up and selection criteria of patients with NELM being considered for liver transplantation. Thereafter, we provide a critical analysis of the reported outcomes of OLT.
综述目的
局限于肝脏的神经内分泌肿瘤（NET）转移是肝移植的公认适应证，因为此类肿瘤在恶性程度方面生物学侵袭性较低且生长缓慢。
最新发现
长期结果与原发性肝癌肝移植相当，在某些情况下甚至更好。然而，与非恶性疾病相比，神经内分泌肝转移（NELM）可能导致移植效果较差。鉴于供体器官稀缺以及近期NELM非手术治疗效果改善，肝移植患者选择和时机的争议仍在继续。
总结
在本综述中，我们概述了考虑进行肝移植的NELM患者的诊断检查和选择标准。此后，我们对原位肝移植（OLT）的报告结果进行了批判性分析。
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