Kim Kwangmin, Shin In Sik, Bang Hui-Jae, An Sanghyun, Ha Gaesung, Kim Hyun Soo, Bae Keum Seok
Department of Surgery Yonsei University Wonju College of Medicine Wonju South Korea.
Trauma Center Wonju Severance Christian Hospital Wonju South Korea.
JGH Open. 2020 Dec 17;5(2):320-323. doi: 10.1002/jgh3.12466. eCollection 2021 Feb.
Several studies have described the effectiveness of mesenchymal stem cell (MSC) transplantation in patients with liver cirrhosis (LC). However, in the majority, biochemical tests, clinical features, and pathologic results were used rather than radiologic tests to compare treatment outcomes. A 57-year-old male visited a stem cell clinic with a diagnosis of LC attributed to hepatitis B virus. This patient took tenofovir and diuretics at the initial presentation and was administered bone marrow-derived MSCs twice via hepatic intra-arterial infusion. Subsequently, the patient's clinical symptoms and biochemical tests (aspartate aminotransferase, alanine aminotransferase, albumin, total bilirubin, international normalized ratio, creatinine, alpha-fetoprotein) improved. Computed tomography findings showed loss of ascites, reduced nodularity, and especially increased liver volume, which suggested that MSCs have meaningful effects on liver volume, as well as improving liver function.
多项研究描述了间充质干细胞（MSC）移植对肝硬化（LC）患者的有效性。然而，大多数研究使用生化检查、临床特征和病理结果，而非影像学检查来比较治疗效果。一名57岁男性因乙型肝炎病毒导致的肝硬化就诊于一家干细胞诊所。该患者初诊时服用替诺福韦和利尿剂，并通过肝动脉内输注接受了两次骨髓来源的间充质干细胞治疗。随后，患者的临床症状和生化检查（天冬氨酸转氨酶、丙氨酸转氨酶、白蛋白、总胆红素、国际标准化比值、肌酐、甲胎蛋白）有所改善。计算机断层扫描结果显示腹水消失、结节减少，尤其是肝脏体积增加，这表明间充质干细胞对肝脏体积有显著影响，同时也改善了肝功能。
