Michals K, Lopus M, Matalon R
Department of Nutrition, University of Illinois, Chicago 60612.
Biochem Med Metab Biol. 1988 Feb;39(1):18-23. doi: 10.1016/0885-4505(88)90053-9.
The data from this study showed that the excretion of three major metabolites of phenylalanine in patients with PKU approach normal values at blood phenylalanine levels less than 5.0 mg/dl. The MANOVA showed statistically significant differences in phenyllactate excretion when blood phenylalanine was greater than 10.0 mg/dl. The PL and total metabolite excretion were significantly correlated to blood phenylalanine in multiple samples taken from two individual subjects. Using data obtained from single patient observations may serve as a means for individualizing the PKU diet to insure low levels of phenylalanine metabolites and thus insure optimal development for patients with PKU.
该研究数据表明，苯丙酮尿症（PKU）患者体内苯丙氨酸的三种主要代谢产物在血液苯丙氨酸水平低于5.0mg/dl时，其排泄量接近正常值。多变量方差分析（MANOVA）显示，当血液苯丙氨酸水平高于10.0mg/dl时，苯乳酸排泄存在统计学显著差异。在从两名个体受试者采集的多个样本中，苯乳酸（PL）和总代谢产物排泄与血液苯丙氨酸显著相关。利用从单个患者观察中获得的数据，可作为使PKU饮食个体化的一种方法，以确保苯丙氨酸代谢产物处于低水平，从而确保PKU患者的最佳发育。
