膀胱癌转移分布的性别和年龄相关性差异。

Sex- and age-related differences in the distribution of bladder cancer metastases.

机构信息

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada.

Department of Urology and Division of Experimental Oncology, Urological Research Institute, IBCAS San Raffaele Scientific Institute, Milan, Italy.

出版信息

Jpn J Clin Oncol. 2021 May 28;51(6):976-983. doi: 10.1093/jjco/hyaa273.

DOI:10.1093/jjco/hyaa273

PMID:33558890

Abstract

OBJECTIVE

Our objective was to investigate age- and sex-related differences in the distribution of metastases in patients with metastatic bladder cancer.

METHODS

Within the National Inpatient Sample database (2008-2015), we identified 7040 patients with metastatic bladder cancer. Trend test and Chi-square test analyses were used to evaluate the relationship between age and site of metastases, according to sex.

RESULTS

Of 7040 patients with metastatic bladder cancer, 5226 (74.2%) were men and 1814 (25.8%) were women. Thoracic, abdominal, bone and brain metastases were present in 19.5 vs. 23.0%, 43.6 vs. 46.9%, 23.9 vs. 18.7% and 2.4 vs. 2.9% of men vs. women, respectively. Bone was the most common metastatic site in men (23.9%) vs. lung in women (22.4%). Increasing age was associated with decreasing rates of abdominal (from 44.9 to 40.2%) and brain (from 3.2 to 1.4%) metastases in men vs. decreasing rates of bone (from 21.0 to 13.3%) and brain (from 5.1 to 2.0%) metastases in women (all P < 0.05). Finally, rates of metastases in multiple organs also decreased with age, in both men and women.

CONCLUSIONS

The distribution of metastases in bladder cancer varies according to sex. Moreover, differences exist according to patient age and these differences are also sex-specific. In consequence, patient age and sex should be considered in the interpretation of imaging, especially when findings are indeterminate.

摘要

目的

本研究旨在探讨转移性膀胱癌患者转移部位的分布与年龄和性别之间的关系。

方法

在国家住院患者样本数据库（2008-2015 年）中，我们共确定了 7040 例转移性膀胱癌患者。采用趋势检验和卡方检验分析，根据性别评估年龄与转移部位之间的关系。

结果

在 7040 例转移性膀胱癌患者中，男性 5226 例（74.2%），女性 1814 例（25.8%）。男性中，胸部、腹部、骨骼和脑部转移分别占 19.5%、43.6%、23.9%和 2.4%，而女性中分别占 23.0%、46.9%、18.7%和 2.9%。男性最常见的转移部位是骨骼（23.9%），而女性最常见的转移部位是肺部（22.4%）。随着年龄的增长，男性腹部（从 44.9%降至 40.2%）和脑部（从 3.2%降至 1.4%）转移的发生率降低，而女性骨骼（从 21.0%降至 13.3%）和脑部（从 5.1%降至 2.0%）转移的发生率也降低（均 P<0.05）。最后，男性和女性的多个器官转移率也随着年龄的增长而降低。