Bigot-Corbel Edith, Lanore Aymeric, Raulet Celia, Delorme Cécile, Azulay Jean-Philippe, Lehmann Sylvain, Beaudeux Jean-Louis, Beauvieux Marie-Christine, Sapin Vincent, Peoc'h Katell, Rucheton Benoit
Laboratoire de biochimie, CHU de Nantes, Hôpital Laënnec, Saint-Herblain, France.
Département de Neurologie, APHP, Sorbonne-Université, Hôpital Pitié-Salpêtrière, Paris, France.
Ann Biol Clin (Paris). 2021 Feb 1;79(1):7-16. doi: 10.1684/abc.2021.1622.
Soon after the pandemic, numerous publications described cases of neurological disorders associated with the SARS-CoV-2 infection. The range of neurological symptoms is becoming increasingly more extensive as the pandemic progresses. However, it is not yet well established whether the manifestations are due to direct viral damage to the nervous system or indirect consequences of the infection. This review presents an inventory of the biochemical markers studied in the context of neurological disorders related to SARS-CoV-2. By reflecting various physiopathological mechanisms, these biomarkers allow both a better understanding of the pathophysiology of Covid-19 and a contribution to the diagnosis of neurologic troubles; they could participate in the prognostic evaluation of patients.
疫情爆发后不久,众多出版物描述了与SARS-CoV-2感染相关的神经疾病病例。随着疫情的发展,神经症状的范围越来越广泛。然而,这些表现是由于病毒对神经系统的直接损害还是感染的间接后果,目前尚未明确。本综述列出了在与SARS-CoV-2相关的神经疾病背景下研究的生化标志物清单。通过反映各种生理病理机制,这些生物标志物既有助于更好地理解新冠病毒病的病理生理学,也有助于神经疾病的诊断;它们可以参与患者的预后评估。