评估皮肤利什曼病患者的巯基/二硫键平衡。
Evaluation of thiol/disulphide balance in patients with cutaneous leishmaniasis.
机构信息
Department of Dermatology, Ahlat State Hospital, Bitlis, Turkey.
Department of Dermatology, Harran University Medical Faculty, Şanlıurfa, Turkey.
出版信息
Int J Clin Pract. 2021 Jun;75(6):e14087. doi: 10.1111/ijcp.14087. Epub 2021 Feb 19.
OBJECTIVE
The aim of this study was to evaluate serum thiol disulphide levels in patients with cutaneous leishmaniasis (CL) compared with a healthy control group and to investigate whether thiol/disulphide balance can be used as a new marker of oxidative stress in CL patients.
MATERIAL AND METHODS
This prospective study included 47 patients diagnosed with CL and 46 healthy individuals without any disease. Native thiol, disulphide and total thiol levels were used in plasma. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol levels were measured.
RESULTS
Disulphide, native thiol disulphide and total thiol disulphide levels were significantly lower in CL patients compared with the control group. However, there was no statistically significant difference between CL patients and the control group in terms of disulphide/native thiol, disulphide/total thiol and native thiol/total thiol values.
CONCLUSION
Based on the data in our study, it can be said that the use of thiol/disulphide balance as a new oxidative stress marker in CL patients is not appropriate, but studies with a larger number of patients are needed.
目的
本研究旨在评估皮肤利什曼病（CL）患者与健康对照组的血清巯基二硫键水平，并探讨巯基/二硫键平衡是否可作为 CL 患者氧化应激的新标志物。
材料和方法
本前瞻性研究纳入了 47 例确诊为 CL 的患者和 46 例无任何疾病的健康个体。使用血浆中的内源性巯基、二硫键和总巯基水平。测量二硫键/总巯基、二硫键/内源性巯基和内源性巯基/总巯基比值。
结果
与对照组相比，CL 患者的二硫键、内源性巯基二硫键和总巯基二硫键水平显著降低。然而，CL 患者和对照组之间的二硫键/内源性巯基、二硫键/总巯基和内源性巯基/总巯基比值无统计学差异。
结论
根据本研究数据，可以说使用巯基/二硫键平衡作为 CL 患者氧化应激的新标志物是不合适的，但需要进行更多患者的研究。
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