鉴定饮食诱导的 2 型糖尿病小鼠模型中对伯克霍尔德氏菌假单胞菌感染的早期免疫反应缺陷。

Identification of defective early immune responses to Burkholderia pseudomallei infection in a diet-induced murine model of type 2 diabetes.

机构信息

College of Medicine and Dentistry, James Cook University, Queensland, 4811, Australia.

College of Public Health, Medical and Veterinary Sciences, James Cook University, Queensland, 4811, Australia.

出版信息

Microbes Infect. 2021 May-Jun;23(4-5):104793. doi: 10.1016/j.micinf.2021.104793. Epub 2021 Feb 8.

DOI:10.1016/j.micinf.2021.104793

PMID:33571673

Abstract

Co-occurrence of bacterial infections with type 2 diabetes (T2D) is a global problem. Melioidosis caused by Burkholderia pseudomallei is 10 times more likely to occur in patients with T2D, than in normoglycemic individuals. Using an experimental model of T2D, we observed that greater susceptibility in T2D was due to differences in proportions of infiltrating leucocytes and reduced levels of MCP-1, IFN-γ and IL-12 at sites of infection within 24 h post-infection. However, by 72 h the levels of inflammatory cytokines and bacteria were markedly higher in visceral tissue and blood in T2D mice. In T2D, dysregulated early immune responses are responsible for the greater predisposition to B. pseudomallei infection.

摘要

2 型糖尿病（T2D）合并细菌感染是一个全球性问题。比格氏杆菌引起的类鼻疽在 T2D 患者中的发生率比血糖正常个体高 10 倍。我们通过 T2D 实验模型发现，24 小时感染后，T2D 患者白细胞浸润比例差异和 MCP-1、IFN-γ 和 IL-12 水平降低导致 T2D 患者易感性增加。然而，72 小时时，T2D 小鼠内脏组织和血液中的炎症细胞因子和细菌水平明显升高。在 T2D 中，早期免疫反应失调导致对 B. pseudomallei 感染的易感性增加。