预防性输卵管卵巢切除术对韩国 BRCA 基因突变携带者生活质量的影响。

Effect of risk-reducing salpingo-oophorectomy on the quality of life in Korean BRCA mutation carriers.

机构信息

Department of Surgery, Kyung Hee University College of Medicine, Kyung Hee University Medical Center, Seoul, South Korea.

Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

出版信息

Asian J Surg. 2021 Aug;44(8):1056-1062. doi: 10.1016/j.asjsur.2021.01.007. Epub 2021 Feb 8.

DOI:10.1016/j.asjsur.2021.01.007

PMID:33573923

Abstract

BACKGROUND

This study aimed to compare the quality of life (QOL), psychosocial status, sexual function, and menopausal symptoms between the risk-reducing salpingo-oophorectomy (RRSO) and non-RRSO groups comprising BRCA mutation carriers and to evaluate the effect of timing of RRSO on those aspects.

METHODS

This cross-sectional study recruited BRCA mutation carriers aged ≥35 years between September 2015 and September 2016. Demographic data of carriers were collected. Outcomes were measured using the questionnaires addressing QOL, anxiety, depression, optimism, sexual function, and menopausal symptoms.

RESULTS

Of 52 participants, 30 (57.7%) underwent RRSO, whereas 22 (42.3%) did not. In the RRSO group, 16 (53.3%) and 14 (46.7%) women underwent RRSO before and after menopause, respectively. The mean age in the RRSO group was higher than that in the non-RRSO group (49.8 vs. 42.1 years, respectively, p = 0.002). The scores for QOL, anxiety, depression, optimism, sexual function, and menopausal symptoms were similar between both groups. In the multivariate analysis, RRSO uptake was associated with worse physical QOL (coefficient, -5.350; 95% confidence interval, -10.593 to -0.108). With respect to the timing of RRSO, only the mental QOL was significantly lower in the postmenopausal RRSO group than in the premenopausal RRSO group (39.2 vs. 43.7, respectively, p = 0.043).

CONCLUSION

We could not find any difference in mental QOL, psychosocial status, sexual function, and menopausal symptoms between the RRSO and non-RRSO groups. RRSO uptake only affected worse physical QOL. These results will help physicians counsel BRCA mutation carriers about the effect of RRSO on QOL.

摘要

背景

本研究旨在比较接受预防性输卵管卵巢切除术（RRSO）和未接受 RRSO 的 BRCA 基因突变携带者的生活质量（QOL）、心理社会状态、性功能和更年期症状，并评估 RRSO 时机对这些方面的影响。

方法

本横断面研究于 2015 年 9 月至 2016 年 9 月招募了年龄≥35 岁的 BRCA 基因突变携带者。收集携带者的人口统计学数据。使用问卷调查 QOL、焦虑、抑郁、乐观、性功能和更年期症状。

结果

在 52 名参与者中，30 名（57.7%）接受了 RRSO，22 名（42.3%）未接受 RRSO。在 RRSO 组中，16 名（53.3%）和 14 名（46.7%）女性分别在绝经前和绝经后接受 RRSO。RRSO 组的平均年龄高于未 RRSO 组（分别为 49.8 岁和 42.1 岁，p=0.002）。两组的 QOL、焦虑、抑郁、乐观、性功能和更年期症状评分相似。在多变量分析中，RRSO 的采用与较差的身体 QOL 相关（系数，-5.350；95%置信区间，-10.593 至-0.108）。关于 RRSO 的时机，仅绝经后 RRSO 组的心理 QOL 明显低于绝经前 RRSO 组（分别为 39.2 分和 43.7 分，p=0.043）。