Tompkins Kathleen, Juliano Jonathan J, van Duin David
Division of Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States.
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States.
Front Med (Lausanne). 2021 Jan 26;8:615649. doi: 10.3389/fmed.2021.615649. eCollection 2021.
Antibiotic resistant (formerly ) are a growing threat to Sub-Saharan Africa. Genes causing antibiotic resistance are easily spread between the environment and humans and infections due to drug resistant organisms contribute to sepsis mortality via delayed time to appropriate antimicrobial therapy. Additionally, second or third-line antibiotics are often not available or are prohibitively expensive in resource-constrained settings leading to limited treatment options. Lack of access to water and sanitation facilities, unregulated use of antibiotics, and malnutrition are contributors to high rates of antibiotic resistance in the region. Improvements in the monitoring of drug resistant infections and antibiotic stewardship are needed to preserve the efficacy of antibiotics for the future.
抗生素耐药性（以前称为 ）对撒哈拉以南非洲构成了日益严重的威胁。导致抗生素耐药性的基因很容易在环境和人类之间传播，耐药生物体引起的感染会因延迟获得适当抗菌治疗的时间而导致败血症死亡率上升。此外，在资源有限的环境中，二线或三线抗生素往往无法获得或价格高得令人望而却步，导致治疗选择有限。缺乏安全饮用水和卫生设施、抗生素的无节制使用以及营养不良是该地区抗生素耐药率高的原因。需要改进对耐药性感染的监测和抗生素管理，以保持抗生素在未来的疗效。
