Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Department of Neurology, Nanjing Drum Tower Hospital of The Affiliated Hospital of Nanjing University Medical School, and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China.
J Alzheimers Dis. 2021;80(2):577-590. doi: 10.3233/JAD-201376.
Self-referential processing is associated with the progression of Alzheimer's disease (AD), and cerebrospinal fluid (CSF) proteins have become accepted biomarkers of AD.
Our objective in this study was to focus on the relationships between the self-referential network (SRN) and CSF pathology in AD-spectrum patients.
A total of 80 participants, including 20 cognitively normal, 20 early mild cognitive impairment (EMCI), 20 late MCI (LMCI), and 20 AD, were recruited for this study. Independent component analysis was used to explore the topological SRN patterns, and the abnormalities of this network were identified at different stages of AD. Finally, CSF pathological characteristics (i.e., CSF Aβ, t-tau, and p-tau) that affected the abnormalities of the SRN were further determined during the progression of AD.
Compared to cognitively normal subjects, AD-spectrum patients (i.e., EMCI, LMCI, and AD) showed a reversing trend toward an association between CSF pathological markers and the abnormal SRN occurring during the progression of AD. However, a certain disease state (i.e., the present LMCI) with a low concentration of CSF tau could evoke more hyperconnectivity of the SRN than other patients with progressively increasing concentrations of CSF tau (i.e., EMCI and AD), and this fluctuation of CSF tau was more sensitive to the hyperconnectivity of the SRN than the dynamic changes of CSF Aβ.
The integrity of the SRN was closely associated with CSF pathological characteristics, and these findings support the view that the hyperconnectivity of the SRN will play an important role in monitoring the progression of the pre-dementia state to AD.
自我参照处理与阿尔茨海默病（AD）的进展有关，脑脊液（CSF）蛋白已成为 AD 的公认生物标志物。
本研究旨在关注 AD 谱系患者的自我参照网络（SRN）与 CSF 病理学之间的关系。
共招募了 80 名参与者，包括 20 名认知正常者、20 名早期轻度认知障碍（EMCI）患者、20 名晚期轻度认知障碍（LMCI）患者和 20 名 AD 患者。采用独立成分分析（ICA）探讨拓扑 SRN 模式，确定 AD 不同阶段该网络的异常。最后，确定 AD 进展过程中影响 SRN 异常的 CSF 病理特征（即 CSF Aβ、t-tau 和 p-tau）。
与认知正常者相比，AD 谱系患者（即 EMCI、LMCI 和 AD）在 CSF 病理标志物与 AD 进展过程中 SRN 异常之间的关联呈反向趋势。然而，在 CSF tau 浓度较低的特定疾病状态（即目前的 LMCI）中，SRN 的超连接程度比 CSF tau 浓度逐渐增加的其他患者（即 EMCI 和 AD）更高，CSF tau 的这种波动比 CSF Aβ 的动态变化对 SRN 的超连接更敏感。
SRN 的完整性与 CSF 病理特征密切相关，这些发现支持这样一种观点，即 SRN 的超连接将在监测前驱痴呆状态向 AD 进展中发挥重要作用。
Zotero 插件