暴露于选择性 5-羟色胺再摄取抑制剂或 5-羟色胺去甲肾上腺素再摄取抑制剂与性功能障碍：来自在线调查的结果。

Exposure to serotonin selective reuptake inhibitors or serotonin noradrenaline reuptake inhibitors and sexual dysfunction: Results from an online survey.

机构信息

Department of Health Sciences, University of Florence, Florence, Italy.

Clinical Pharmacopsychology Laboratory, University of Florence, Florence, Italy.

出版信息

Int J Risk Saf Med. 2021;32(3):229-242. doi: 10.3233/JRS-200074.

DOI:10.3233/JRS-200074

PMID:33579876

Abstract

BACKGROUND

Post-SSRI Sexual Dysfunction (PSSD) is characterized by sexual and emotional symptoms associated to the exposure to Selective Serotonin Reuptake Inhibitors (SSRI) or Serotonin Noradrenaline Reuptake Inhibitors (SNRI).

OBJECTIVE

The present study provides a comprehensive picture on demographic and clinical characteristics associated to PSSD.

METHODS

An online survey was run on subjects self-declaring as affected by PSSD. The survey collected socio-demographic and clinical data via questions created ad hoc and three standardized scales (Arizona Sexual Experiences Scale, Hospital Anxiety and Depression Scale, World Health Organization Wellbeing Index).

RESULTS

A total of 135 subjects (115 males; mean age 31.9 ± 8.9 years) was analysed. The syndrome was more represented among young, heterosexual males after the exposure to SSRI/SNRI at relatively high doses. The major findings involved the temporal sequence of symptoms: 118 subjects had symptoms both during and after SSRI/SNRI administration, and 17 only after, thus deposing for a iatrogenic action of SSRI/SNRI. Different variables, represented by both emotional and sexual symptoms, accounted for the variability of the severity of the sexual dysfunction as well as of wellbeing.

CONCLUSIONS

Based on the present results, PSSD is a complex iatrogenic syndrome in need of being further studied and understood.

摘要

背景

抗抑郁药后性功能障碍（PSSD）的特征是与选择性 5-羟色胺再摄取抑制剂（SSRIs）或 5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRIs）暴露相关的性和情感症状。

目的

本研究提供了与 PSSD 相关的人口统计学和临床特征的综合描述。

方法

对自我报告患有 PSSD 的受试者进行了在线调查。该调查通过专门创建的问题和三个标准化量表（亚利桑那性体验量表、医院焦虑和抑郁量表、世界卫生组织幸福感量表）收集了社会人口统计学和临床数据。

结果

共分析了 135 名受试者（115 名男性；平均年龄 31.9 ± 8.9 岁）。该综合征在年轻、异性恋男性中更为常见，他们在暴露于相对较高剂量的 SSRIs/SNRIs 后出现该综合征。主要发现涉及症状的时间顺序：118 名受试者在 SSRIs/SNRIs 治疗期间和之后都有症状，而 17 名受试者仅在之后有症状，因此 SSRIs/SNRIs 具有医源性作用。不同的变量，包括情感和性症状，解释了性功能障碍严重程度以及幸福感的可变性。