Department of Internal Medicine, Division of Medical Oncology, Gazi Yasargil Training and Research Hospital, Kayapınar, Diyarbakir, Turkey.
Department of Nuclear Medicine, Gazi Yasargil Training and Research Hospital, Kayapınar, Diyarbakir, Turkey.
Ann Nucl Med. 2021 May;35(5):540-548. doi: 10.1007/s12149-021-01594-8. Epub 2021 Feb 14.
To evaluate the relationship between whole body volumetric (Wbv) results of Ga-PSMA PET/CT with biochemical and histopathological parameters.
One hundred twenty-one prostate cancer patients who underwent Ga-PSMA PET/CT between January 2018 and December 2019 were included. Imaging was conducted for staging upon new diagnosis with moderate- and high-risk disease and for confirming the progression of castration resistance. The relationships between the Wbv Ga-PSMA PET/CT parameters and prostate-specific antigen (PSA) levels, PSA doubling time and Gleason score (GS) were evaluated.
The median GS and mean PSA levels were similar between the castration-naive and resistant patients. The PSA levels were positively correlated with MTVwb (p: 0.009, r: 0.286) and TLPwb (p: 0.002, r: 0.344). Gleason scores were positively correlated with MTVwb (p: 0.050, r: 0.216), TLPwb (p: 0.007, r: 0.296) and highest standard uptake value (HSUV) max (p: 0.047, r: 0.220). In the castration-naive group, Gleason scores (from p < 0.001 to p = 0.04 and r = 0.331 to 0.549) and PSA levels (from p = 0.002 to p = 0.045 and from r = 0.323 to 0.473) correlated with all Ga-PSMA-PET/CT parameters. PSA doubling time was negatively correlated with whole-body metabolic tumour volume (MTVwb) (p: 0.050, r: 0.232) and whole-body total lesion PSMA (TLPwb) (p: 0.026, r: 0.262). The MTVwb, TLPwb and HSUVpeak values of the patients with biochemical recurrence (BR) of 0-6 months (n = 18) were higher than those with BR > 2 years (n = 35) (p = 0.046, 0.047 and 0.042, respectively).
Wbv Ga-PSMA PET/CT results were correlated with PSA levels and Gleason scores. The correlation was relatively stronger in the castration-naive group. The prognostic accuracy of PSA in the resistant group may be weaker than in the naive group. The difference in volumetric parameters of patients with short BR compared to long BR supports the idea that Ga-PSMA PET/CT can distinguish patients with rapid relapse from others.
评估 Ga-PSMA PET/CT 的全身容积（Wbv）结果与生化和组织病理学参数之间的关系。
纳入 2018 年 1 月至 2019 年 12 月期间进行 Ga-PSMA PET/CT 的 121 例前列腺癌患者。对中高危疾病的新诊断进行分期成像，并进行影像学检查以确认去势抵抗的进展。评估 Wbv Ga-PSMA PET/CT 参数与前列腺特异性抗原（PSA）水平、PSA 倍增时间和 Gleason 评分（GS）之间的关系。
初诊时无去势抵抗和有去势抵抗的患者 GS 中位数和平均 PSA 水平相似。PSA 水平与 MTVwb 呈正相关（p：0.009，r：0.286）和 TLPwb（p：0.002，r：0.344）。GS 与 MTVwb（p：0.050，r：0.216）、TLPwb（p：0.007，r：0.296）和最高标准摄取值（HSUV）max（p：0.047，r：0.220）呈正相关。在无去势抵抗组中，GS（从 p < 0.001 到 p = 0.04 和 r = 0.331 到 0.549）和 PSA 水平（从 p = 0.002 到 p = 0.045 和 r = 0.323 到 0.473）与所有 Ga-PSMA-PET/CT 参数相关。PSA 倍增时间与全身代谢肿瘤体积（MTVwb）（p：0.050，r：0.232）和全身总病变 PSMA（TLPwb）（p：0.026，r：0.262）呈负相关。生化复发（BR）0-6 个月（n = 18）患者的 MTVwb、TLPwb 和 HSUVpeak 值高于 BR > 2 年（n = 35）患者（p = 0.046、0.047 和 0.042）。
Wbv Ga-PSMA PET/CT 结果与 PSA 水平和 Gleason 评分相关。在无去势抵抗组中，相关性相对较强。在有抵抗组中，PSA 的预后准确性可能比无抵抗组弱。与 BR 较长的患者相比，BR 较短的患者的容积参数存在差异，这支持 Ga-PSMA PET/CT 可以区分快速复发的患者和其他患者的观点。
