甲状腺癌中的植物化学物：临床前研究分析。
Phytochemicals in thyroid cancer: analysis of the preclinical studies.
机构信息
Department of Health Sciences, University "Magna Graecia" of Catanzaro, Viale Europa, Germaneto, 88100, Catanzaro, Italy.
Department of Translational and Precision Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
出版信息
Endocrine. 2021 Jul;73(1):8-15. doi: 10.1007/s12020-021-02651-y. Epub 2021 Feb 15.
PURPOSE
In the search for novel effective compounds to use in thyroid cancer (TC) unresponsive to current treatment, attention has recently focused on plant-derived compounds with anticancer activity. In this review, we discuss the preclinical studies demonstrating phytochemical activity against thyroid cancer cells.
RESULTS/CONCLUSIONS: In particular, we describe their antiproliferative properties or ability to re-induce iodine retention, thus supporting their potential use as single agents or adjuvants in radioiodine-resistant thyroid cancer treatment.
目的
在寻找新型有效化合物以治疗对当前治疗无反应的甲状腺癌 (TC) 时，最近人们的注意力集中在具有抗癌活性的植物源性化合物上。在这篇综述中，我们讨论了证明植物化学物质对甲状腺癌细胞具有活性的临床前研究。
结果/结论：特别是，我们描述了它们的抗增殖特性或重新诱导碘摄取的能力，因此支持它们作为单一药物或放射性碘难治性甲状腺癌治疗的辅助药物的潜在用途。
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