School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Key Laboratory of Vision Science, Ministry of Health, Wenzhou, Zhejiang, China.
Semin Ophthalmol. 2021 Feb 17;36(1-2):2-8. doi: 10.1080/08820538.2021.1881567. Epub 2021 Feb 15.
: To investigate the efficacy of preoperative monocular treatment in elderly cataract patients with Meibomian Gland Dysfunction (MGD) utilizing vectored thermal pulsation treatment.: This study was a prospective, examiner-masked contralateral eye clinical trial. Patients previously diagnosed with MGD undergoing uncomplicated cataract surgery in two eyes were enrolled. The eye perceived by the patient to be more symptomatic of MGD received a 12 min vectored thermal pulsation treatment using the LipiFlow Thermal Pulsation System, and was referred to as the LipiFlow-surgery eye. The contralateral eye then served as the nonLipiFlow-surgery eye. Patients with MGD not undergoing cataract surgery were enrolled as the control group. Within the control group, the eye that received LipiFlow treatment was considered the LipiFlow-nonsurgery eye, while the contralateral eye served as the nonLipiFlow-nonsurgery eye. All patients were examined before treatment and at one-week, one-month, and three-month intervals after treatment. Clinical parameters included dry eye symptoms, average lipid layer thickness (LLT-ave), tear breakup time (TBUT), corneal staining, Schirmer I tests, Meibomian glands yielding liquid secretion (MGYLS), and meibomian gland dropout.: A total of 32 patients (64 eyes) were examined during the three-month follow-up. There was a significant reduction in dry eye symptoms in non-surgery patients with monocular treatment of MGD, while no change in surgery patients was observed. Significant improvement of MGYLS in LipiFlow-surgery and LipiFlow-nonsurgery eyes during the follow-up time ( < .001) was reported, while no difference was observed in nonLipiFlow-surgery and nonLipiFlow-nonsurgery eyes. A statistically significant difference was seen in TBUT between LipiFlow-surgery and nonLipiFlow-surgery eyes at one-week and one-month intervals ( = .019 and 0.019, respectively). Differences in other clinical parameters were not statistically significant.: Our findings suggest that although subjective symptoms were not alleviated, a single application of LipiFlow treatment before cataract surgery is effective in alleviating blockage of meibomian glands and preventing the decline of TBUT after cataract surgery.
: 研究术前单眼治疗老年白内障合并睑板腺功能障碍（MGD）患者的疗效：这是一项前瞻性、研究者设盲的对侧眼临床试验。招募了双侧眼均诊断为 MGD 且接受单纯白内障手术的患者。患者自述 MGD 症状较重的眼接受了 12 分钟的vectored thermal pulsation 治疗（使用 LipiFlow 热脉动系统），称为 LipiFlow-手术眼。对侧眼作为非 LipiFlow-手术眼。未接受白内障手术的 MGD 患者作为对照组。在对照组中，接受 LipiFlow 治疗的眼为 LipiFlow-非手术眼，对侧眼为非 LipiFlow-非手术眼。所有患者在治疗前和治疗后 1 周、1 个月和 3 个月进行检查。临床参数包括干眼症状、平均脂质层厚度（LLT-ave）、泪膜破裂时间（TBUT）、角膜染色、Schirmer I 试验、睑板腺分泌液体（MGYLS）和睑板腺缺失。在 3 个月的随访中，共检查了 32 例（64 只眼）患者。单眼治疗 MGD 的非手术患者干眼症状明显减轻，而手术患者无变化。LipiFlow-手术眼和 LipiFlow-非手术眼的 MGYLS 在随访期间显著改善（ < 0.001），而非 LipiFlow-手术眼和非 LipiFlow-非手术眼无差异。LipiFlow-手术眼和非 LipiFlow-手术眼在治疗后 1 周和 1 个月时的 TBUT 差异有统计学意义（分别为 0.019 和 0.019）。其他临床参数的差异无统计学意义。：我们的研究结果表明，尽管主观症状没有缓解，但白内障手术前单次应用 LipiFlow 治疗可有效缓解睑板腺阻塞，防止白内障手术后 TBUT 下降。
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