Department of Cardiothoracic Surgery and Transplantation, Clinical Science, Lund University, Skane University Hospital, Lund, Sweden.
Department of Cardiology, Clinical Sciences, Lund University, Skane University Hospital, Lund, Sweden.
Int Wound J. 2021 Oct;18(5):681-691. doi: 10.1111/iwj.13570. Epub 2021 Feb 16.
Patients with arteriolosclerosis have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract has shown to have a positive impact on vascular elasticity. The present study aimed to assess the effect of long-term treatment with AGE on peripheral tissue perfusion in patients with confirmed atherosclerosis. Ninety three patients with a CT-scan confirmed coronary artery arteriolosclerosis were randomised in a double-blind manner to placebo or 2400 mg AGE daily for 1 year. Peripheral tissue perfusion was evaluated at 0- and 12-months using Laser Speckle Contrast Imaging. Measurement of post occlusive reactive hyperemia (PORH) and cutaneous vascular conductance (CVC) using acetylcholine iontophoresis (Ach) was conducted. After 12 months a significant increase of 21.6% (95% CI 3.2%-40.0%, P < .05) was seen in the relative change of PORH in the AGE compared with the placebo group. The same response was seen for CVC and Ach with an increase of 21.4% (95% CI 3.4%-39.4%, P < .05) in the AGE group compared with the placebo group. Aged garlic extract regenerated peripheral tissue perfusion and increase microcirculation in patients with arteriolosclerosis. Adequate peripheral tissue perfusion and tissue oxygen tension are important prerequisites for successful tissue repair. Restored microcirculation in patients could hypothetically facilitate wound healing.
患有细动脉硬化症的患者微血管灌注受损，导致伤口愈合不良。大蒜提取物已被证明对血管弹性有积极影响。本研究旨在评估长期使用 AGE 对已确诊动脉粥样硬化患者外周组织灌注的影响。93 名经 CT 扫描证实的冠状动脉细动脉硬化症患者以双盲方式随机分为安慰剂组或每天 2400mg AGE 组，治疗 1 年。使用激光散斑对比成像在 0 个月和 12 个月时评估外周组织灌注。使用乙酰胆碱离子电渗法（Ach）测量闭塞后反应性充血（PORH）和皮肤血管传导性（CVC）。12 个月后，AGE 组 PORH 的相对变化增加了 21.6%（95%CI 3.2%-40.0%，P<0.05），与安慰剂组相比有显著差异。CVC 和 Ach 也有同样的反应，AGE 组比安慰剂组增加了 21.4%（95%CI 3.4%-39.4%，P<0.05）。大蒜提取物可使细动脉硬化症患者的外周组织灌注和微循环再生。适当的外周组织灌注和组织氧张力是成功组织修复的重要前提。患者的微循环恢复理论上可以促进伤口愈合。
