Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695019, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Org Lett. 2021 Mar 5;23(5):1814-1819. doi: 10.1021/acs.orglett.1c00219. Epub 2021 Feb 16.
We have developed a metal-free, mild, and green synthetic route toward benzothieno[3,2-]benzofurans by the annulation of 3-nitrobenzothiophene with phenols. The reaction was found to be general with a range of substituted phenols. In addition, we could extend the methodology for the synthesis of pentacenes and could demonstrate the synthesis in gram-scale. Moreover, we extended the strategy for the synthesis of benzothieno[2,3-]benzofurans by starting from 2-nitrobenzothiophenes.
我们开发了一种无金属、温和、绿色的苯并噻吩[3,2-b]苯并呋喃合成方法，通过 3-硝基苯并噻吩与酚类化合物的环化反应实现。该反应具有广泛的取代酚类化合物的通用性。此外，我们可以将该方法扩展到并五苯的合成，并在克级规模上进行了演示。此外，我们通过从 2-硝基苯并噻吩开始，扩展了合成苯并噻吩[2,3-b]苯并呋喃的策略。
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