Department of Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.
South West London Elective Orthopaedic Centre, Epsom, UK.
Bone Joint J. 2021 Apr;103-B(4):681-688. doi: 10.1302/0301-620X.103B.BJJ-2020-1776.R1. Epub 2021 Feb 16.
The primary aim was to assess the rate of postoperative COVID-19 following hip and knee arthroplasty performed in March 2020 in the UK. The secondary aims were to assess whether there were clinical factors associated with COVID-19 status, the mortality rate of patients with COVID-19, and the rate of potential COVID-19 in patients not presenting to healthcare services.
A multicentre retrospective study was conducted of patients undergoing hip or knee arthroplasty during the first wave of the COVID-19 pandemic (1 March 2020 to 31 March 2020) with a minimum of 60 days follow-up. Patient demographics, American Society of Anesthesiologists grade, procedure type, primary or revision, length of stay (LOS), COVID-19 test status, and postoperative mortality were recorded. A subgroup of patients (n = 211) who had not presented to healthcare services after discharge were contacted and questioned as to whether they had symptoms of COVID-19.
Five (0.5%) of 1,073 patients who underwent hip or knee arthroplasty tested positive for SARS-CoV-2 postoperatively. When adjusting for confounding factors, increasing LOS (p = 0.022) was the only significant factor associated with developing COVID-19 following surgery and a stay greater than three days was a reliable predictor with an area under the curve of 81% (p = 0.018). There were three (0.3%) deaths in the study cohort and the overall mortality rate attributable to COVID-19 was 0.09% (n = 1/1,073), with one (20%) of the five patients with COVID-19 dying postoperatively. Of the 211 patients contacted, two had symptoms within two to 14 days postoperatively with a positive predictive value of 31% and it was therefore estimated that one patient may have had undiagnosed COVID-19.
The rate of postoperative COVID-19 was 0.5% and may have been as high as 1% when accounting for those patients not presenting to healthcare services, which was similar to the estimated population prevalence during the study period. The overall mortality rate secondary to COVID-19 was low (0.09%), however the mortality rate for those patients developing COVID-19 was 20%. Cite this article: 2021;103-B(4):681-688.
本研究的主要目的是评估英国 2020 年 3 月行髋膝关节置换术后的 COVID-19 术后发病率。次要目的是评估与 COVID-19 状态相关的临床因素、COVID-19 患者的死亡率以及未向医疗保健机构就诊的患者中 COVID-19 的潜在发病率。
本研究为多中心回顾性研究,纳入 2020 年 3 月 1 日至 3 月 31 日期间行髋膝关节置换术的患者,术后至少随访 60 天。记录患者的人口统计学资料、美国麻醉医师协会分级、手术类型(初次或翻修)、住院时间( LOS )、COVID-19 检测状态和术后死亡率。对出院后未向医疗保健机构就诊的患者( n = 211 )进行亚组分析,询问其是否有 COVID-19 症状。
1073 例髋膝关节置换术患者中,5 例(0.5%)术后 SARS-CoV-2 检测呈阳性。在校正混杂因素后,LOS 增加( p = 0.022 )是术后发生 COVID-19 的唯一显著相关因素,LOS 大于 3 天是可靠的预测因素,曲线下面积为 81%( p = 0.018 )。研究队列中有 3 例(0.3%)死亡,COVID-19 所致的总死亡率为 0.09%( n = 1/1073 ),5 例 COVID-19 患者中有 1 例(20%)术后死亡。在联系的 211 例患者中,2 例在术后 2 至 14 天内出现症状,阳性预测值为 31%,因此估计有 1 例患者可能患有未确诊的 COVID-19。
术后 COVID-19 的发病率为 0.5%,当考虑到未向医疗保健机构就诊的患者时,可能高达 1%。COVID-19 所致的总死亡率较低(0.09%),但发生 COVID-19 的患者死亡率为 20%。
2021;103-B(4):681-688.