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英国在停止择期手术服务之前,择期髋关节和膝关节置换术后 COVID-19 及相关死亡率。

The rate of COVID-19 and associated mortality after elective hip and knee arthroplasty prior to cessation of elective services in UK.

机构信息

Department of Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.

South West London Elective Orthopaedic Centre, Epsom, UK.

出版信息

Bone Joint J. 2021 Apr;103-B(4):681-688. doi: 10.1302/0301-620X.103B.BJJ-2020-1776.R1. Epub 2021 Feb 16.

Abstract

AIMS

The primary aim was to assess the rate of postoperative COVID-19 following hip and knee arthroplasty performed in March 2020 in the UK. The secondary aims were to assess whether there were clinical factors associated with COVID-19 status, the mortality rate of patients with COVID-19, and the rate of potential COVID-19 in patients not presenting to healthcare services.

METHODS

A multicentre retrospective study was conducted of patients undergoing hip or knee arthroplasty during the first wave of the COVID-19 pandemic (1 March 2020 to 31 March 2020) with a minimum of 60 days follow-up. Patient demographics, American Society of Anesthesiologists grade, procedure type, primary or revision, length of stay (LOS), COVID-19 test status, and postoperative mortality were recorded. A subgroup of patients (n = 211) who had not presented to healthcare services after discharge were contacted and questioned as to whether they had symptoms of COVID-19.

RESULTS

Five (0.5%) of 1,073 patients who underwent hip or knee arthroplasty tested positive for SARS-CoV-2 postoperatively. When adjusting for confounding factors, increasing LOS (p = 0.022) was the only significant factor associated with developing COVID-19 following surgery and a stay greater than three days was a reliable predictor with an area under the curve of 81% (p = 0.018). There were three (0.3%) deaths in the study cohort and the overall mortality rate attributable to COVID-19 was 0.09% (n = 1/1,073), with one (20%) of the five patients with COVID-19 dying postoperatively. Of the 211 patients contacted, two had symptoms within two to 14 days postoperatively with a positive predictive value of 31% and it was therefore estimated that one patient may have had undiagnosed COVID-19.

CONCLUSION

The rate of postoperative COVID-19 was 0.5% and may have been as high as 1% when accounting for those patients not presenting to healthcare services, which was similar to the estimated population prevalence during the study period. The overall mortality rate secondary to COVID-19 was low (0.09%), however the mortality rate for those patients developing COVID-19 was 20%. Cite this article:  2021;103-B(4):681-688.

摘要

目的

本研究的主要目的是评估英国 2020 年 3 月行髋膝关节置换术后的 COVID-19 术后发病率。次要目的是评估与 COVID-19 状态相关的临床因素、COVID-19 患者的死亡率以及未向医疗保健机构就诊的患者中 COVID-19 的潜在发病率。

方法

本研究为多中心回顾性研究,纳入 2020 年 3 月 1 日至 3 月 31 日期间行髋膝关节置换术的患者,术后至少随访 60 天。记录患者的人口统计学资料、美国麻醉医师协会分级、手术类型(初次或翻修)、住院时间( LOS )、COVID-19 检测状态和术后死亡率。对出院后未向医疗保健机构就诊的患者( n = 211 )进行亚组分析,询问其是否有 COVID-19 症状。

结果

1073 例髋膝关节置换术患者中,5 例(0.5%)术后 SARS-CoV-2 检测呈阳性。在校正混杂因素后,LOS 增加( p = 0.022 )是术后发生 COVID-19 的唯一显著相关因素,LOS 大于 3 天是可靠的预测因素,曲线下面积为 81%( p = 0.018 )。研究队列中有 3 例(0.3%)死亡,COVID-19 所致的总死亡率为 0.09%( n = 1/1073 ),5 例 COVID-19 患者中有 1 例(20%)术后死亡。在联系的 211 例患者中,2 例在术后 2 至 14 天内出现症状,阳性预测值为 31%,因此估计有 1 例患者可能患有未确诊的 COVID-19。

结论

术后 COVID-19 的发病率为 0.5%,当考虑到未向医疗保健机构就诊的患者时,可能高达 1%。COVID-19 所致的总死亡率较低(0.09%),但发生 COVID-19 的患者死亡率为 20%。

引用本文

2021;103-B(4):681-688.

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