针灸治疗老年新型冠状病毒肺炎（COVID-19）患者的疗效和安全性：系统评价和荟萃分析方案。
Efficacy and safety of acupuncture for elderly patients with coronavirus disease 2019 (COVID-19): A protocol for systematic review and meta-analysis.
机构信息
College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
出版信息
Medicine (Baltimore). 2021 Feb 5;100(5):e24515. doi: 10.1097/MD.0000000000024515.
BACKGROUND
The study aims to evaluate the effectiveness and safety of acupuncture therapy for elderly patients with coronavirus disease 2019 (COVID-19).
METHODS
Relevant articles from December 2019 to December 2020 will be searched in the following electronic databases: Medline, PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), and China Scientific Journals Database. All published randomized controlled trials (RCTs) and credible clinical observations about this topic will be included. Two independent researchers will operate article retrieval, duplication removing, screening and data analysis by EndNote X9.0 and Stata 15.0. We will use the Cochrane risk of bias tool for randomized trials to assess the risk of bias of included studies. Meta-analysis, subgroup analysis, and/or descriptive analysis will be performed according to the data conditions included.
RESULTS
High-quality synthesis and/or descriptive analysis of current evidence will be provided from mortality rate, cure rate, C-reactive protein (CRP), creatine, troponin, aspartate aminotransferase, alanine aminotransferase, and improvements in chest CT scans, clinical symptoms (including fever, fatigue, cough, nausea, vomiting and diarrhea) and the side effects of acupuncture.
CONCLUSION
This study will provide evidence of whether acupuncture is an effective and safe intervention for the elderly with COVID-19.
PROSPERO REGISTRATION NUMBER
CRD42020225245.
背景
本研究旨在评估针刺疗法对老年新型冠状病毒肺炎（COVID-19）患者的疗效和安全性。
方法
将在以下电子数据库中检索 2019 年 12 月至 2020 年 12 月期间的相关文献：Medline、PubMed、EMBASE、Web of Science、Cochrane 图书馆、中国知网（CNKI）、中国生物医学文献数据库（CBM）和中国科学引文数据库（CSCD）。纳入所有关于该主题的已发表的随机对照试验（RCT）和可信临床观察。两名独立的研究人员将使用 EndNote X9.0 和 Stata 15.0 进行文章检索、去重、筛选和数据分析。我们将使用 Cochrane 偏倚风险工具评估纳入研究的偏倚风险。根据纳入的数据情况，将进行荟萃分析、亚组分析和/或描述性分析。
结果
将从死亡率、治愈率、C 反应蛋白（CRP）、肌酸、肌钙蛋白、天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、胸部 CT 扫描改善、临床症状（包括发热、乏力、咳嗽、恶心、呕吐和腹泻）以及针刺的不良反应等方面，对当前证据进行高质量综合和/或描述性分析。
结论
本研究将为针刺是否是 COVID-19 老年患者有效且安全的干预措施提供证据。
PROSPERO 注册号：CRD42020225245。
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