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阿片肽基因在前列腺癌生长和进展中的作用。

Role of opiorphin genes in prostate cancer growth and progression.

机构信息

Department of Urology, Albert Einstein College of Medicine/Montefiore Medical Center, NY 10461, USA.

Department of Physiology & Biophysics, Albert Einstein College of Medicine/Montefiore Medical Center, NY 10461, USA.

出版信息

Future Oncol. 2021 Jun;17(17):2209-2223. doi: 10.2217/fon-2020-1299. Epub 2021 Feb 17.

DOI:10.2217/fon-2020-1299
PMID:33593085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8293029/
Abstract

We describe the first studies investigating a role for opiorphin genes (, and ) in prostate cancer (PrCa). Databases and PrCa tissue arrays were screened for opiorphin expression. Xenografted tumor growth of human PrCa cells overexpressing was compared with controls in nude mice. Modulated gene expression by overexpression of was determined by RNA sequencing. PrCa is associated with overexpression of opiorphin genes. Xenografted androgen-sensitive PrCa cells overexpressing developed into tumors in castrated male mice (in contrast to parental cells). overexpression modulates expression of genes in angiogenesis, steroid and hypoxic response pathways. Opiorphins promote the development of androgen-insensitive PrCa and activate pathways that potentially overcome the hypoxic barrier generated during tumor growth.

摘要

我们描述了首次研究(opiorphin 基因在前列腺癌中的作用的研究)。数据库和前列腺癌组织阵列筛选 opiorphin 表达。在裸鼠中比较过表达 的人前列腺癌细胞的异种移植肿瘤生长与对照。通过 RNA 测序确定 过表达对基因表达的调节。前列腺癌与 opiorphin 基因的过度表达有关。过表达 的雄激素敏感性前列腺癌细胞在去势雄性小鼠中发展为肿瘤（与亲本细胞相反）。过表达调节血管生成、类固醇和缺氧反应途径中的基因表达。Opiorphins 促进雄激素不敏感前列腺癌的发展，并激活潜在克服肿瘤生长过程中产生的缺氧屏障的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/9f1a5f4fd74b/fon-17-2209-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/835dd467cfcb/fon-17-2209-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/b432828dd157/fon-17-2209-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/167e39b2e355/fon-17-2209-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/85fe513e1599/fon-17-2209-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/9f1a5f4fd74b/fon-17-2209-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/835dd467cfcb/fon-17-2209-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/b432828dd157/fon-17-2209-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/167e39b2e355/fon-17-2209-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/85fe513e1599/fon-17-2209-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69a/8293029/9f1a5f4fd74b/fon-17-2209-g5.jpg

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Exp Ther Med. 2019 Nov;18(5):3579-3587. doi: 10.3892/etm.2019.7998. Epub 2019 Sep 11.
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Identification of potential key genes and pathways predicting pathogenesis and prognosis for triple-negative breast cancer.
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预测三阴性乳腺癌发病机制和预后的潜在关键基因及通路的鉴定
Cancer Cell Int. 2019 Jun 28;19:172. doi: 10.1186/s12935-019-0884-0. eCollection 2019.
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World J Oncol. 2019 Apr;10(2):63-89. doi: 10.14740/wjon1191. Epub 2019 Apr 20.
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