Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Republic of Korea.
Department of Medical Statistics, Daegu Catholic University School of Medicine, Daegu, Republic of Korea.
Lupus. 2021 Apr;30(4):655-660. doi: 10.1177/0961203321995247. Epub 2021 Feb 16.
The purpose of this study was to investigate the epidemiology of immune thrombocytopenia (ITP) under the copayment waiver policy for pediatric patients in Korea. The data were collected from the National Health Insurance Claims Database of Korea. ITP was identified based on the diagnostic code D69.38 from the Korean Standard Classification of Diseases. Patients between one and 18 years old, who had at least one health insurance claim for ITP as a final diagnosis, from 1 January 2016, to 31 December 2017, were analyzed. Prevalent cases were defined as patients who used, at least one time, any medical services coded as D69.38. Incident cases were defined as patients who did not use D69.38 coded medical services during the prior year and were newly registered in 2017. The prevalence and incidence of ITP were 24.53 and 13.39 per 100,000 persons. The peak rates were observed in 1-year-old patients. The gender-specific prevalence of ITP was significantly higher in one-year-old males than females. According to the change-point analysis, we found that the prevalence and incidence diminished rapidly at the ages of four and three, respectively. This Korean population-based epidemiological study of ITP provided meaningful insights into the current epidemiology of ITP and demonstrated the implications of interpreting epidemiologic studies to reflect age categorizing and health care system characteristics.
本研究旨在调查韩国儿童患者免共付额政策下特发性血小板减少性紫癜(ITP)的流行病学。数据来自韩国国家健康保险索赔数据库。ITP 是根据韩国疾病分类标准的诊断代码 D69.38 确定的。分析了 2016 年 1 月 1 日至 2017 年 12 月 31 日期间年龄在 1 至 18 岁之间、至少有一次 ITP 作为最终诊断的健康保险索赔的患者。现患病例定义为至少使用过一次任何以 D69.38 编码的医疗服务的患者。新发病例定义为在前一年未使用过 D69.38 编码的医疗服务且在 2017 年新登记的患者。ITP 的患病率和发病率分别为 24.53 和 13.39/100000 人。发病率峰值出现在 1 岁的患者中。1 岁男性患者的特发性血小板减少性紫癜的性别特异性患病率明显高于女性。根据转折点分析,我们发现患病率和发病率分别在 4 岁和 3 岁时迅速下降。这项基于韩国人群的 ITP 流行病学研究提供了 ITP 当前流行病学的有意义的见解,并表明解释流行病学研究以反映年龄分类和医疗保健系统特征的重要性。