万古霉素诱导心搏骤停：一例报告。
Vancomycin induced cardiac arrest: a case report.
机构信息
Department of Anesthesiology and Intensive Care, National Trauma Centre, National Academy of Medical Sciences, Kathmandu, Nepal.
Department of Anesthesiology and Intensive Care, National Trauma Centre, Kathmandu, Nepal.
出版信息
J Med Case Rep. 2021 Feb 16;15(1):77. doi: 10.1186/s13256-020-02639-8.
BACKGROUND
Rapid intravenous administration of vancomycin may manifest with histaminergic responses with clinical features ranging from mild rashes, pruritus and even shock. This case reports of a child, who was accidentally given intravenous vancomycin within minutes and had a cardiac arrest.
CASE PRESENTATION
A 9-year-old Asian girl who was scheduled for a limb salvage surgery, received vancomycin preoperatively. As a result of rapid infusion of the drug, the patient developed flushing, pruritus and had respiratory distress with hypotension leading to asystole. However, prompt detection and immediate cardiopulmonary resuscitation revived the patient in time following which sound recovery ensued. We recognised inadvertent brisk infusion of vancomycin as the culprit with strong suspicion of Red Man Syndrome.
CONCLUSION
Red Man Syndrome, though rarely encountered, can always be life threatening. With a surge in the use of vancomycin, adverse effects associated with its use also rises. So a comprehensive knowledge regarding its rationale use, adverse effects and its prompt management in personnel prescribing it, can be life saving.
背景
万古霉素快速静脉输注可能会引起组胺能反应，其临床特征从轻度皮疹、瘙痒甚至休克不等。本病例报告了一名儿童，因意外在数分钟内静脉注射万古霉素而导致心脏骤停。
病例介绍
一名 9 岁亚裔女孩因计划进行肢体挽救手术，术前接受了万古霉素治疗。由于药物快速输注，患者出现潮红、瘙痒，并伴有低血压导致的呼吸窘迫和心搏停止。然而，及时发现并立即进行心肺复苏使患者及时复苏，随后恢复良好。我们认为意外快速输注万古霉素是罪魁祸首，强烈怀疑为红人综合征。
结论
红人综合征虽然很少见，但可能会危及生命。随着万古霉素使用的增加，其相关副作用也随之增加。因此，对于开具该药的人员来说，全面了解其合理使用、不良反应及其及时管理，可以起到救命的作用。
Zotero 插件