幼年时期使用西地那非治疗对 Sprague-Dawley 大鼠和弗林德斯敏感线大鼠的长期生物行为影响。
The long-term bio-behavioural effects of juvenile sildenafil treatment in Sprague-Dawley versus flinders sensitive line rats.
机构信息
Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
出版信息
Acta Neuropsychiatr. 2021 Aug;33(4):200-205. doi: 10.1017/neu.2021.4. Epub 2021 Feb 17.
OBJECTIVE
To investigate the long-term effects of juvenile sub-chronic sildenafil (SIL) treatment on the depressive-like behaviour and hippocampal brain-derived neurotrophic factor (BDNF) levels of adult Sprague-Dawley (SD) versus Flinders Sensitive Line (FSL) rats.
METHODS
SD and FSL rats were divided into pre-pubertal and pubertal groups, whereafter 14-day saline or SIL treatment was initiated. Pre-pubertal and pubertal rats were treated from postnatal day 21 (PND21) and PND35, respectively. The open field and forced swim tests (FST) were performed on PND60, followed by hippocampal BDNF level analysis 1 day later.
RESULTS
FSL rats displayed greater immobility in the FST compared to SD rats (p < 0.0001), which was reduced by SIL (p < 0.0001), regardless of treatment period. Hippocampal BDNF levels were unaltered by SIL in all treatment groups (p > 0.05).
CONCLUSION
Juvenile sub-chronic SIL treatment reduces the risk of depressive-like behaviour manifesting during young adulthood in genetically susceptible rats.
目的
研究幼年亚慢性西地那非（SIL）治疗对成年 Sprague-Dawley（SD）大鼠与 Flinders 敏感系（FSL）大鼠抑郁样行为和海马脑源性神经营养因子（BDNF）水平的长期影响。
方法
将 SD 和 FSL 大鼠分为青春期前和青春期两组，然后开始为期 14 天的盐水或 SIL 治疗。青春期前和青春期大鼠分别从出生后第 21 天（PND21）和 PND35 开始治疗。在 PND60 时进行旷场和强迫游泳试验（FST），之后 1 天分析海马 BDNF 水平。
结果
FSL 大鼠在 FST 中的不动时间明显长于 SD 大鼠（p < 0.0001），而 SIL 处理（p < 0.0001）则降低了这种差异，无论治疗时期如何。在所有治疗组中，SIL 对海马 BDNF 水平均无影响（p > 0.05）。
结论
幼年亚慢性 SIL 治疗可降低易患抑郁样行为的遗传敏感大鼠在成年早期出现抑郁样行为的风险。
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