Research Centre, Douglas Research Centre, Montreal, Québec, Canada.
Department of Psychiatry, McGill University, Montreal, Québec, Canada.
BMJ Open. 2021 Feb 16;11(2):e038409. doi: 10.1136/bmjopen-2020-038409.
Socioeconomic status (SES) affects physical and mental health and cognitive functioning. The association between SES changes (SES mobility) and health has ethical and political implications in that the pernicious effects of inequality and the differential impact on social classes of economic and social policies. There is a lack of research conducted to explore the intergenerational transmission of parental SES changes on the offspring's mental health and cognitive functioning. We aim to fill this gap and identify roles of parental SES changes in offspring's mental health and cognitive outcomes.
This study will be based on a longitudinal cohort from the most populous municipality in the Canadian province of Quebec. Participants and their biological offspring will be invited to this study. For those with informed consent, we will collect their information on mental health, psychiatric disorders, cognitive functioning and early life experiences for offspring. Latent class growth analysis will be used to identify parental SES mobility groups. Multivariate regression analyses will be used to explore the roles of early life stress, parental SES mobility and their interactions in psychiatric disorders and cognitive functioning. Subgroup analyses (males and females) are also planned.
This study has been given ethical approval by the Research Ethics Board of the Douglas Mental Health University Institute (IUSMD-18/17). Each participant will provide informed consent on participation. We will disseminate research findings through publication in peer-reviewed academic journals and presentations at conferences. Lay summaries of major research findings will also be shared annually with our partners in the health system and community agencies located in the catchment area.
社会经济地位(SES)会影响身心健康和认知功能。SES 变化(SES 流动性)与健康之间的关联具有伦理和政治意义,因为不平等的有害影响以及经济和社会政策对社会阶层的不同影响。缺乏研究探索父母 SES 变化对子代心理健康和认知功能的代际传递。我们旨在填补这一空白,并确定父母 SES 变化对子代心理健康和认知结果的作用。
本研究将基于加拿大魁北克省人口最多的城市的一项纵向队列研究。将邀请参与者及其亲生子女参加这项研究。对于那些有知情同意的人,我们将收集他们的心理健康、精神疾病、认知功能和后代早期生活经历的信息。潜在类别增长分析将用于识别父母 SES 流动性群体。多元回归分析将用于探索早期生活压力、父母 SES 流动性及其相互作用在精神疾病和认知功能中的作用。还计划进行亚组分析(男性和女性)。
这项研究已获得道格拉斯心理健康大学研究所研究伦理委员会(IUSMD-18/17)的批准。每个参与者将在参与前提供知情同意。我们将通过在同行评议的学术期刊上发表研究结果和在会议上展示来传播研究结果。主要研究结果的通俗摘要也将每年与我们在该流域地区的卫生系统和社区机构的合作伙伴分享。