Department of Neurology, New York University Long Island School of Medicine, Mineola, NY; and.
Department of Neurology, University of Washington Medical Center, Seattle, WA.
J Clin Neuromuscul Dis. 2021 Mar 1;22(3):169-172. doi: 10.1097/CND.0000000000000334.
Multifocal motor neuropathy with conduction block (MMN) and anti-myelin-associated glycoprotein (MAG) neuropathy are rare chronic acquired demyelinating neuropathies with distinct clinical and electrophysiological characteristics. These neuropathies are generally not known to coexist. This report describes a patient with long-standing MMN who subsequently developed clinical features of anti-MAG neuropathy. This suggests that subtypes of chronic inflammatory neuropathies may not be sharply defined. In addition, a presentation of MMN with anti-MAG titers may be a prognostic indicator of poor response to standard MMN treatment.
多灶性运动神经病伴传导阻滞（MMN）和抗髓鞘相关糖蛋白（MAG）神经病是两种罕见的慢性获得性脱髓鞘神经病，具有独特的临床和电生理特征。这些神经病通常不会同时存在。本报告描述了一例长期患有 MMN 的患者，随后出现了抗 MAG 神经病的临床特征。这表明慢性炎症性神经病的亚型可能没有明确的界定。此外，MMN 出现抗 MAG 滴度可能是对标准 MMN 治疗反应不佳的预后指标。
