Soltani Elham Reza, Tahvildari Kambiz, Moniri Elham, Panahi Homayoun Ahmad
Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran,Iran.
Department of Chemistry, Varamin Branch, Islamic Azad University, Varamin,Iran.
Curr Drug Deliv. 2021;18(9):1292-1302. doi: 10.2174/1567201818666210217160759.
Among different 2-D nanostructures, molybdenum disulfide (MoS2) has shown great potential as a good candidate in drug delivery systems. However, their biocompatibility and water dispersibility are the main issues for these purposes. With the aim of improving the MoS2 dispersibility, a novel drug delivery system based on polymer-modified MoS2 nanosheets was successfully prepared and characterized.
In this study, MoS2 nanosheets were prepared using a simple oleum treatment exfoliation approach and then modified by grafting thermos-responsive polymer N- isopropylacrylamide (NIPAM) and polyethylene glycol (PEG). The structural and morphological properties of the MoS2/NIPAM/ PEG nanosheets were characterized via Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Fourier- Transform Infrared Spectroscopy (FTIR), and Thermogravimetric analysis (TGA/DSC). Initially, the adsorption behavior of the grafted nanoadsorbent was assessed for sorption of doxorubicin as an anticancer drug model. The influence of various parameters such as pH, temperature, and contact time was evaluated. Different kinetic and isotherm models were employed to investigate the (DOX) adsorption mechanism.
The obtained results revealed that the DOX adsorption onto the MoS2/NIPAM/ PEG followed the Langmuir isotherm and pseudo-second-order models. In the next step, polymer grafted MoS2 nanosheets were used as thermos-sensitive drug nanocarriers for near-infrared (NIR) photothermal therapy. The combination of chemotherapy and photothermal therapy was also investigated, which indicated a remarkable improvement of cell apoptotic rate compared to monotherapy. Also, MTT assays showed that the MoS2/NIPAM/ PEG had high biocompatibility.
The novel thermo-responsive MoS2/NIPAM/ PEG showed great potential for targeted and controlled drug delivery.
在不同的二维纳米结构中，二硫化钼（MoS₂）作为药物递送系统的优良候选材料展现出了巨大潜力。然而，其生物相容性和水分散性是实现这些目标的主要问题。为了提高MoS₂的分散性，成功制备并表征了一种基于聚合物修饰的MoS₂纳米片的新型药物递送系统。
在本研究中，采用简单的发烟硫酸处理剥离法制备MoS₂纳米片，然后通过接枝热响应性聚合物N-异丙基丙烯酰胺（NIPAM）和聚乙二醇（PEG）进行修饰。通过扫描电子显微镜（SEM）、X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和热重分析（TGA/DSC）对MoS₂/NIPAM/PEG纳米片的结构和形态特性进行了表征。首先，评估了接枝纳米吸附剂对作为抗癌药物模型的阿霉素的吸附行为。评估了诸如pH、温度和接触时间等各种参数的影响。采用不同的动力学和等温线模型研究了阿霉素（DOX）的吸附机制。
所得结果表明，DOX在MoS₂/NIPAM/PEG上的吸附遵循朗缪尔等温线和准二级模型。下一步，将聚合物接枝的MoS₂纳米片用作近红外（NIR）光热疗法的热敏药物纳米载体。还研究了化疗和光热疗法的联合应用，结果表明与单一疗法相比，细胞凋亡率有显著提高。此外，MTT分析表明MoS₂/NIPAM/PEG具有高生物相容性。
新型热响应性MoS₂/NIPAM/PEG在靶向和可控药物递送方面显示出巨大潜力。
