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微小 RNA-9 的新兴分子功能:癌症病理学和治疗意义。

Emerging Molecular Functions of MicroRNA-9: Cancer Pathology and Therapeutic Implications.

机构信息

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Medical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Anticancer Agents Med Chem. 2021;21(17):2304-2314. doi: 10.2174/1871520621666210217094839.

Abstract

MiRNAs that are characterized by small non-coding RNAs orchestrate the expression of important genes involved in cancer cell development processes, including apoptosis, proliferation, angiogenesis, metastasis, and drug resistance at the post-transcriptional level. Dysregulation of miR-9 in various cancers has been reported. Recently, miR-9 has been considered as a key miRNA in various malignancies. However, its importance in the pathogenesis of different neoplasms is not yet well defined. Accordingly, this study was conducted in order to clarify the potential roles of miR-9 in the development of various cancers, prognosis, and treatment approaches. We have shown that a large number of miR-9 targets play fundamental roles in carcinogenesis, and that is dysregulated in various cancer cells. Our findings werefound aberrant miR-9 expression in a majority of cancers. This review article generally emphasizesthe critical roles of miR-9 in cancer cell progression. Additionally, we intended to investigate the effects of down-regulation or up-regulation of miR-9 in different types of cancers. It is hoped that a good understanding of the regulatory roles of miR-9 in various cancers ishelpful for using miR-9 in clinical settings, including prognosis, diagnosis, and miRNA-based target therapy.

摘要

miRNAs 是一类具有小非编码 RNA 特征的分子,它们在转录后水平上协调涉及癌细胞发育过程的重要基因的表达,包括细胞凋亡、增殖、血管生成、转移和耐药性。已经报道了 miR-9 在各种癌症中的失调。最近,miR-9 被认为是各种恶性肿瘤中的关键 miRNA。然而,其在不同肿瘤发生中的重要性尚未得到明确界定。因此,本研究旨在阐明 miR-9 在各种癌症的发病机制、预后和治疗方法中的潜在作用。我们已经表明,大量的 miR-9 靶基因在致癌作用中发挥着重要作用,并且在各种癌细胞中失调。我们发现大多数癌症中存在异常的 miR-9 表达。这篇综述文章重点强调了 miR-9 在癌细胞进展中的关键作用。此外,我们还旨在研究下调或上调 miR-9 在不同类型癌症中的作用。希望对 miR-9 在各种癌症中的调节作用有一个很好的理解,有助于在临床环境中使用 miR-9,包括预后、诊断和基于 miRNA 的靶向治疗。

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