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微血管乳房重建术中椎旁阻滞与腹横肌平面阻滞用于加速康复

Enhanced Recovery With Paravertebral and Transversus Abdominis Plane Blocks in Microvascular Breast Reconstruction.

作者信息

Guffey Ryan, Keane Grace, Ha Austin Y, Parikh Rajiv, Odom Elizabeth, Zhang Li, Myckatyn Terence M

机构信息

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.

Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Breast Cancer (Auckl). 2020 Oct 21;14:1178223420967365. doi: 10.1177/1178223420967365. eCollection 2020.

Abstract

PURPOSE

We have shown previously that a preoperative paravertebral nerve block is associated with improved postoperative recovery in microvascular breast reconstruction. The purpose of this study was to compare the outcomes of a complete enhanced recovery after surgery (ERAS) protocol with complete regional anesthesia coverage to our traditional care with paravertebral block.

PATIENTS AND METHODS

This was a retrospective cohort study of 83 patients who underwent autologous breast reconstruction by T.M.M. between May 2014 and February 2018 at a tertiary academic center. Patients in the ERAS group were additionally administered acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), gabapentin, a transversus abdominis plane block (liposomal or plain bupivacaine), and primarily oral opioids postoperatively. The patients were mobilized earlier with more rapid diet progression. All patients received a preoperative paravertebral block.

RESULTS

Forty-four patients in the ERAS cohort were compared with 39 retrospective controls. The 2 groups were similar with respect to demographics and comorbidities. The ERAS cohort required significantly less opioids (291 vs 707 mg oral morphine equivalent,  < .0001) with unchanged postoperative pain scores and a shorter time to oral only opioid use (16.0 vs 78.2 hours,  < .0001). Median length of stay (3.20 vs 4.62,  < .0001) and time to independent ambulation (1.86 vs 2.88,  < .0001) were also significantly decreased in the ERAS cohort. Liposomal bupivacaine use did not significantly affect the results ( ⩾ .2).

CONCLUSIONS

Implementation of a robust enhanced recovery protocol with complete regional anesthesia coverage was associated with significantly decreased opioid use despite unchanged pain scores, with improved markers of recovery including length of stay, time to oral only narcotics, and time to independent ambulation.

摘要

目的

我们之前已经表明,术前椎旁神经阻滞与微血管乳房重建术后恢复的改善相关。本研究的目的是比较完全增强型术后康复(ERAS)方案加完全区域麻醉覆盖与我们采用椎旁阻滞的传统护理的效果。

患者与方法

这是一项对83例患者进行的回顾性队列研究,这些患者于2014年5月至2018年2月在一家三级学术中心由T.M.M.进行自体乳房重建。ERAS组患者术后还额外给予对乙酰氨基酚、非甾体抗炎药(NSAIDs)、加巴喷丁、腹横肌平面阻滞(脂质体或普通布比卡因),主要为口服阿片类药物。患者更早活动,饮食进展更快。所有患者均接受术前椎旁阻滞。

结果

将ERAS队列中的44例患者与39例回顾性对照患者进行比较。两组在人口统计学和合并症方面相似。ERAS队列所需阿片类药物显著减少(口服吗啡当量分别为291 vs 707mg,<0.0001),术后疼痛评分不变,仅使用口服阿片类药物的时间更短(16.0 vs 78.2小时,<0.0001)。ERAS队列的中位住院时间(3.20 vs 4.62,<0.0001)和独立行走时间(1.86 vs 2.88,<0.0001)也显著缩短。使用脂质体布比卡因对结果无显著影响(≥0.2)。

结论

实施具有完全区域麻醉覆盖的强有力的增强康复方案与阿片类药物使用显著减少相关,尽管疼痛评分不变,恢复指标有所改善,包括住院时间、仅使用口服麻醉剂的时间和独立行走时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf9d/7863148/df91ea322332/10.1177_1178223420967365-fig1.jpg

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