Gwee Sylvia Xiao Wei, St John Ashley L, Gray Gregory C, Pang Junxiong
Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Centre of Infectious Disease Epidemiology and Research, National University of Singapore, Singapore.
One Health. 2021 Jan 20;12:100216. doi: 10.1016/j.onehlt.2021.100216. eCollection 2021 Jun.
Dengue is a rapidly spreading mosquito-borne flavivirus infection that is prevalent in tropical and sub-tropical regions. Humans are known to be the main reservoir host maintaining the epidemic cycles of dengue but it is unclear if dengue virus is also maintained in a similar enzootic cycle. The systematic review was conducted in accordance to Cochrane's PRISMA recommendations. A search was done on PubMed, EMBASE, Scopus and Cochrane Library. Key data on animal dengue positivity was extracted and classified according to animal type and diagnostic modes. Of the 3818 articles identified, 56 articles were used in this review. A total of 16,333 animals were tested, 1817 of which were positive for dengue virus by RT-PCR or serology. Dengue positivity was detected in bats (10.1%), non-human primates (27.3%), birds (11%), bovid (4.1%), dogs (1.6%), horses (5.1%), pigs (34.1%), rodents (3.5%), marsupials (13%) and other small animals (7.3%). While majority of dengue positivity via serology suggests potential enzootic transmission, but regular dengue virus spillback cannot be excluded. With the exception of bats, acute infection among animals is limited. Further investigation on animals is critically required to better understand their role as potential reservoir in dengue transmission.
登革热是一种通过蚊子传播且迅速蔓延的黄病毒感染疾病，在热带和亚热带地区流行。已知人类是维持登革热流行周期的主要储存宿主，但尚不清楚登革热病毒是否也以类似的动物疫源性周期存在。本系统评价按照Cochrane的PRISMA建议进行。在PubMed、EMBASE、Scopus和Cochrane图书馆进行了检索。提取了动物登革热阳性的关键数据，并根据动物类型和诊断方式进行分类。在鉴定出的3818篇文章中，本评价使用了56篇。总共检测了16333只动物，其中1817只通过逆转录聚合酶链反应（RT-PCR）或血清学检测登革热病毒呈阳性。在蝙蝠（10.1%）、非人灵长类动物（27.3%）、鸟类（11%）、牛科动物（4.1%）、狗（1.6%）、马（5.1%）、猪（34.1%）、啮齿动物（3.5%）、有袋动物（13%）和其他小动物（7.3%）中检测到登革热阳性。虽然大多数通过血清学检测的登革热阳性表明可能存在动物疫源性传播，但不能排除登革热病毒定期回溢的情况。除蝙蝠外，动物中的急性感染有限。迫切需要对动物进行进一步调查，以更好地了解它们在登革热传播中作为潜在储存宿主的作用。
