Hinder R A, Fimmel C J, Rickards E, von Ritter C, Svensson L G, Blum A L
Department of Surgery, University of the Witwatersrand, Johannesburg, South Africa.
Dig Dis Sci. 1988 May;33(5):545-51. doi: 10.1007/BF01798355.
In acute experiments carried out in 27 baboons under general anesthesia, the regional gastric mucosal and muscle layer blood flow and gastric acid secretion were measured during 4 hr. Baboons were allocated to each of the following six groups: control, gastric acid stimulation with histamine 40 micrograms/kg/hr intravenous, inhibition of basal or stimulated acid secretion with either ranitidine 50 mg intravenous or omeprazole 1 microgram/kg/hr. There were no significant cardiovascular alterations during the experiments. Histamine stimulation produced a concomitant rise in acid secretion and increase in blood flow only to the mucosal layer of the parietal-cell-bearing area of the stomach. Neither the underlying muscle layer nor the non-parietal-cell-bearing fundic or antral mucosa took part in this response, suggesting that a mechanism controlling blood flow is present in close proximity to the parietal cells. It was also established that the increase in blood flow occurs in response to parietal cell activity and not as a result of the action of histamine on the vascular system. Suppression of both basal and stimulated acid secretion did not cause a fall of mucosal blood flow below basal levels in any part of the stomach, indicating that drugs that inhibit parietal cell activity can be used in conditions where gastric mucosal ischemia should be avoided.
在对27只处于全身麻醉状态的狒狒进行的急性实验中，在4小时内测量了局部胃黏膜和肌层血流量以及胃酸分泌情况。狒狒被分为以下六组：对照组、以40微克/千克/小时的组胺静脉注射刺激胃酸分泌组、分别以50毫克雷尼替丁静脉注射或1微克/千克/小时奥美拉唑抑制基础或刺激胃酸分泌组。实验过程中未出现明显的心血管改变。组胺刺激导致胃酸分泌同时增加，且仅使含壁细胞区域的胃黏膜层血流量增加。胃的底层肌层以及不含壁细胞的胃底或胃窦黏膜均未参与此反应，这表明在壁细胞附近存在一种控制血流量的机制。还证实血流量的增加是对壁细胞活动的反应，而非组胺对血管系统作用的结果。抑制基础和刺激胃酸分泌均未导致胃的任何部位黏膜血流量降至基础水平以下，这表明在应避免胃黏膜缺血的情况下，可使用抑制壁细胞活性的药物。
