Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Ophthalmology, National Kyushu Medical Center, 1-8-1, Jigyo-hama, Chuo-ku, Fukuoka, 8108563, Japan.
Sci Rep. 2021 Feb 18;11(1):4185. doi: 10.1038/s41598-021-83334-6.
Our study assessed the influence of vascular permeability on vascular flow density (FD)-correlated retinal sensitivity (RS) in DR. In this cross-sectional, prospective, consecutive study, RS in the extrafoveal macula of DR patient was measured by microperimetry. FD was measured in the total, superficial, and deep capillary plexus layers (TCP, SCP, and DCP) by optical coherence tomography angiography. All measurement points were classified into four categories according to intensity of fluorescein leakage and FD, and the RS reduction was compared. A stratified analysis by retinal thickness (RT) was also performed. Fourteen eyes (14 patients) were enrolled. FDs at 207 RS measurement points were analyzable. For TCP, SCP and DCP, the leakage did not decrease RS at points where FD was maintained. The greater the leakage, the smaller the RS reduction at points with low FD in TCP (P = .020). Points with high leakage showed a significant smaller RS reduction than points with low leakage (P = .001 for TCP, P = .040 for SCP, and P = .046 for DCP) only in areas with low RT and low FD. Our results suggested that vascular hyperpermeability may inhibit the RS reduction in the non-edematous ischemic diabetic retina.
我们的研究评估了血管通透性对糖尿病视网膜病变（DR）中血管血流密度（FD）相关视网膜敏感性（RS）的影响。在这项横断面、前瞻性、连续研究中，通过微视野计测量 DR 患者的黄斑区中心凹外 RS。通过光相干断层扫描血管造影测量总、浅层和深层毛细血管丛层（TCP、SCP 和 DCP）的 FD。根据荧光素渗漏和 FD 的强度将所有测量点分为四类，并比较 RS 降低情况。还进行了视网膜厚度（RT）分层分析。共纳入 14 只眼（14 例患者）。可分析 207 个 RS 测量点的 FD。对于 TCP、SCP 和 DCP，在 FD 保持的情况下，渗漏不会降低 RS。在 FD 较低的情况下，TCP 中漏出量越大，RS 降低幅度越小（P = .020）。高漏出量组与低漏出量组相比，在低 RT 和低 FD 区域，RS 降低幅度显著较小（TCP 为 P = .001，SCP 为 P = .040，DCP 为 P = .046）。我们的结果表明，血管高通透性可能抑制非水肿性缺血性糖尿病视网膜的 RS 降低。
