Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Japan.
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Langenbecks Arch Surg. 2021 Jun;406(4):1129-1138. doi: 10.1007/s00423-021-02088-x. Epub 2021 Feb 18.
This study aimed to apply the principles of the "Milan criteria" to patients undergoing hepatic resection for CRLM and to evaluate the efficacy of prognostic factors.
The medical records of consecutive patients who underwent curative resection for CRLM from April 2007 to April 2019 were retrospectively reviewed. Time to aggressive treatment failure (TATF) was defined as the time interval from the initial surgery until the first unresectable recurrence or recurrence that could only be treated with doublet or lower dose chemotherapy, or death. The risk factors associated with recurrence-free survival (RFS), TSF, TATF, and overall survival (OS) were evaluated.
On univariate analysis, the Milan criteria significantly predicted long-term OS, TATF, TSF, and RFS. Moreover, the Milan criteria were able to stratify patients with CRLM into distinct prognostic groups with regard to long-term OS, TATF, TSF, and RFS.
Milan criteria, a simple index, are a factor contributing to all the survival time and are a very important factor in discussing the prognosis of CRLM.
本研究旨在将“米兰标准”的原则应用于接受肝切除术治疗结直肠癌肝转移（CRLM）的患者，并评估预后因素的疗效。
回顾性分析 2007 年 4 月至 2019 年 4 月期间连续接受根治性切除治疗 CRLM 的患者的病历。侵袭性治疗失败时间（TATF）定义为从初始手术到首次不可切除复发或仅能采用双药或低剂量化疗治疗的复发，或死亡的时间间隔。评估与无复发生存（RFS）、肿瘤无复发生存（TSF）、TATF 和总生存（OS）相关的风险因素。
单因素分析显示，米兰标准显著预测了长期 OS、TATF、TSF 和 RFS。此外，米兰标准能够将 CRLM 患者分为不同的预后组，与长期 OS、TATF、TSF 和 RFS 相关。
米兰标准是一个简单的指标，是所有生存时间的一个影响因素，是讨论 CRLM 预后的一个非常重要的因素。
Zotero 插件