有建设的时候，也有毁灭的时候：葡萄糖代谢适应四季变化。

A time to build and a time to burn: glucose metabolism for every season.

机构信息

Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA; Division of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA.

出版信息

Mol Cell. 2021 Feb 18;81(4):642-644. doi: 10.1016/j.molcel.2021.02.003.

DOI:10.1016/j.molcel.2021.02.003

PMID:33606971

Abstract

Luengo et al. (2020) demonstrate that pyruvate dehydrogenase (PDH) overactivation blunts NAD regeneration by overcharging the mitochondrial membrane potential and driving ATP synthesis beyond demand. Under these conditions, some cells prioritize aerobic glycolysis to meet the need for oxidized cofactors in biosynthetic metabolism.

摘要

卢恩戈等人（2020 年）证明，丙酮酸脱氢酶（PDH）过度激活通过过度充电线粒体膜电位并推动 ATP 合成超出需求来阻碍 NAD 再生。在这些条件下，一些细胞优先进行有氧糖酵解，以满足生物合成代谢中氧化辅因子的需求。