F-18 FDG PET/CT 检测儿童霍奇金淋巴瘤骨髓累及的诊断性能：荟萃分析。

Diagnostic performance of F-18 FDG PET/CT in the detection of bone marrow involvement in paediatric hodgkin lymphoma: A meta-analysis.

机构信息

Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Department of Nuclear Medicine, College of Medicine, Pusan National University, Yangsan 50612, Republic of Korea; BioMedical Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea; Department of Nuclear Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.

出版信息

Leuk Res. 2021 Mar;102:106525. doi: 10.1016/j.leukres.2021.106525. Epub 2021 Feb 9.

DOI:10.1016/j.leukres.2021.106525

PMID:33607533

Abstract

OBJECTIVES

The present study aimed to investigate the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the detection of bone marrow involvement (BMI) in paediatric Hodgkin lymphoma (HL) through a systematic review and meta-analysis.

METHODS

PubMed, Cochrane, and EMBASE databases were searched from the earliest available date of indexing till March 31, 2020 for studies evaluating the diagnostic performance of F-18 FDG PET/CT in the detection of BMI in paediatric HL.

RESULTS

Across seven studies (1265 patients), the pooled sensitivity of F-18 FDG PET or PET/CT was 0.95 (95% confidence interval [CI]: 0.87-0.98) with heterogeneity (I = 86.2, p < 0.001), and the pooled specificity was 0.97 (95% CI: 0.84-1.00) with heterogeneity (I = 97.2, p < 0.001). Likelihood ratio syntheses provided an overall positive likelihood ratio of 37.8 (95% CI: 5.2-274.9) and a negative likelihood ratio of 0.05 (95% CI: 0.02-0.14). The pooled diagnostic odds ratio was 732 (95% CI: 55-9806). The area under the summary receiver operating characteristic curve was 0.98 (95% CI: 0.97-0.99).

CONCLUSIONS

The present meta-analysis revealed high sensitivity and specificity of F-18 FDG PET/CT for the detection of BMI in paediatric HL. Currently, the literature regarding the use of F-18 FDG PET/CT for the detection of BMI in paediatric HL is limited. Large multicentre studies are necessary to substantiate the diagnostic accuracy of F-18 FDG PET/CT in the detection of BMI in paediatric HL.

ADVANCES IN KNOWLEDGE

Through a meta-analysis, this study provided a more reliable assessment of the diagnostic utility of F-18 FDG PET/CT, which exhibited good diagnostic accuracy in the detection of BMI in paediatric HL.

摘要

目的

本研究旨在通过系统评价和荟萃分析，探讨 18F 氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）在诊断儿科霍奇金淋巴瘤（HL）骨髓受累（BMI）中的诊断性能。

方法

从最早的索引日期到 2020 年 3 月 31 日，检索 PubMed、Cochrane 和 EMBASE 数据库，以评估 18F FDG PET/CT 在诊断儿科 HL 中 BMI 的诊断性能的研究。

结果

在 7 项研究（1265 例患者）中，18F FDG PET 或 PET/CT 的汇总敏感性为 0.95（95%置信区间[CI]：0.87-0.98），存在异质性（I=86.2，p<0.001），汇总特异性为 0.97（95%CI：0.84-1.00），存在异质性（I=97.2，p<0.001）。似然比综合分析提供了一个总的阳性似然比为 37.8（95%CI：5.2-274.9）和一个阴性似然比为 0.05（95%CI：0.02-0.14）。汇总诊断优势比为 732（95%CI：55-9806）。汇总受试者工作特征曲线下面积为 0.98（95%CI：0.97-0.99）。