雌激素受体 alpha 1 与 TMJ 功能障碍的关联：一项初步研究。
Association of estrogen receptor alpha 1 and TMJ dysfunction: A pilot study.
机构信息
Full Professor, School of Medicine, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba-PR, Brazil.
Assistant Professor, School of Dentistry at Marquette University, Milwaukee, WI, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Apr;131(4):e89-e94. doi: 10.1016/j.oooo.2020.11.010. Epub 2020 Nov 28.
OBJECTIVE
Temporomandibular disorder (TMD) is a multifactorial condition and the most common cause of orofacial pain, affecting mostly women, which points to a female hormone predilection. Therefore, the aim of this study was to analyze the association between TMD and estrogen receptor alpha 1 expression in disks of patients with TMD and condyle fracture (CFx).
STUDY DESIGN
Forty specimens (from 27 patients) included n = 8 CFx, n = 21 anterior disk displacement with reduction (ADDwR), and n = 11 anterior disk displacement without reduction (ADDwoR). Age, area, and intensity of immunostaining were statistically compared between CFx, ADDwR, and ADDwoR groups using analysis of variance and Kruskal-Wallis analysis (P < .05).
RESULTS
No significant difference between CFx, ADDwR, and ADDwoR groups with respect to age and expression of estrogen receptor alpha 1 was observed on immunohistochemical examination.
CONCLUSION
No association of estrogen receptor alpha 1 expression and age was found in the CFx, ADDwR, and ADDwoR groups.
目的
颞下颌关节紊乱（TMD）是一种多因素疾病，也是最常见的口面痛病因，主要影响女性，这表明女性激素有易感性。因此，本研究旨在分析 TMD 患者关节盘和髁突骨折（CFx）中雌激素受体 α1 表达与 TMD 的关系。
研究设计
40 个标本（来自 27 名患者），包括 n = 8 CFx、n = 21 可复性关节盘前移位（ADDwR）和 n = 11 不可复性关节盘前移位（ADDwoR）。采用方差分析和 Kruskal-Wallis 分析（P <.05）对 CFx、ADDwR 和 ADDwoR 组的年龄、面积和免疫染色强度进行统计学比较。
结果
在免疫组织化学检查中，CFx、ADDwR 和 ADDwoR 组之间在年龄和雌激素受体 α1 表达方面无显著差异。
结论
CFx、ADDwR 和 ADDwoR 组中未发现雌激素受体 α1 表达与年龄之间存在关联。
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