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作者信息
Klann Kevin, Münch Christian
机构信息
Institut Biochemie II, Universitätsklinikum, Universität Frankfurt a. M., Theodor-Stern-Kai 7, D-60590 Frankfurt a. M., Deutschland.
Frankfurt Cancer Institute, Frankfurt A. M., Deutschland.
出版信息
Biospektrum (Heidelb). 2021;27(1):40-45. doi: 10.1007/s12268-021-1535-3. Epub 2021 Feb 12.
Upon infection with SARS-CoV-2, a variety of changes happen inside the host cell. The virus hijacks host cell pathways for driving its own replication, while the host counteracts with response mechanisms. To gain a comprehensive understanding of COVID-19, caused by SARS-CoV-2 infection, and develop therapeutic strategies, it is crucial to observe these systematic changes in their entirety. In our recent studies, we followed the effects of SARS-CoV-2 infection on the human proteome, which led to the identification of several drugs that abolished viral proliferation in cells.
感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后，宿主细胞内会发生多种变化。病毒劫持宿主细胞途径以驱动自身复制，而宿主则通过反应机制进行对抗。为了全面了解由SARS-CoV-2感染引起的2019冠状病毒病（COVID-19）并制定治疗策略，全面观察这些系统性变化至关重要。在我们最近的研究中，我们追踪了SARS-CoV-2感染对人类蛋白质组的影响，这导致鉴定出几种可消除细胞中病毒增殖的药物。
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