正常受试者及4例特发性肾性低尿酸血症患者对次黄嘌呤和黄嘌呤的肾脏处理情况。

Renal handling of hypoxanthine and xanthine in normal subjects and in four cases of idiopathic renal hypouricemia.

作者信息

Kaneko K, Fujimori S, Itoh H, Nakayama Y, Oyama H, Kanbayashi T, Miyashita H, Akaoka I

机构信息

Second Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

J Rheumatol. 1988 Feb;15(2):325-30.

PMID:3361540

Abstract

Pyrazinamide (PZA) was used to study the renal handling of hypoxanthine, xanthine and uric acid in 2 normal subjects and in 4 patients with idiopathic renal hypouricemia; one patient was classified as having a postsecretory reabsorption defect, whereas the others were classified as having a presecretory reabsorption defect. In normal subjects, PZA suppressed strongly the excretion of xanthine as well as uric acid; however, it showed a weak effect on that of hypoxanthine. PZA suppressed all excretion of these 3 compounds in the patient with postsecretory reabsorption defect. PZA showed almost no effect on the excretion of either hypoxanthine, xanthine or uric acid in the patients with presecretory reabsorption defect.

摘要

吡嗪酰胺（PZA）被用于研究2名正常受试者和4名特发性肾性低尿酸血症患者体内次黄嘌呤、黄嘌呤和尿酸的肾脏处理情况；1名患者被归类为具有分泌后重吸收缺陷，而其他患者被归类为具有分泌前重吸收缺陷。在正常受试者中，PZA强烈抑制黄嘌呤以及尿酸的排泄；然而，它对次黄嘌呤的排泄作用较弱。PZA抑制了分泌后重吸收缺陷患者体内这3种化合物的所有排泄。PZA对分泌前重吸收缺陷患者的次黄嘌呤、黄嘌呤或尿酸排泄几乎没有影响。