EZH2 在癌症中的非典型作用。
The noncanonical role of EZH2 in cancer.
机构信息
College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, China.
Department of Hematology, Rheumatology, and Infectious Disease, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
出版信息
Cancer Sci. 2021 Apr;112(4):1376-1382. doi: 10.1111/cas.14840. Epub 2021 Feb 24.
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2). Dysregulation of EZH2 causes alteration of gene expression and functions, thereby promoting cancer development. The regulatory function of EZH2 varies across different tumor types. The canonical role of EZH2 is gene silencing through catalyzing the trimethylation of lysine 27 of histone H3 (H3K27me3) in a PRC2-dependent manner. Accumulating evidence indicates that EZH2 has an H3K27me3-independent function as a transcriptional coactivator and plays a critical role in cancer initiation, development, and progression. In this review, we summarize the regulation and function of EZH2 and focus on the current understanding of the noncanonical role of EZH2 in cancer.
增强子结合锌指蛋白 2（EZH2）是多梳抑制复合物 2（PRC2）的催化亚基。EZH2 的失调导致基因表达和功能的改变，从而促进癌症的发展。EZH2 的调节功能因不同的肿瘤类型而异。EZH2 的典型作用是通过依赖于 PRC2 的方式催化组蛋白 H3 赖氨酸 27 的三甲基化（H3K27me3）来实现基因沉默。越来越多的证据表明，EZH2 具有作为转录共激活因子的 H3K27me3 非依赖性功能，并在癌症的起始、发展和进展中发挥关键作用。在这篇综述中，我们总结了 EZH2 的调节和功能，并重点介绍了目前对 EZH2 在癌症中非典型作用的理解。
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