The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
The People's Hospital of Henan Province, Zhengzhou, Henan, 450003, China.
Future Oncol. 2021 Jun;17(17):2193-2208. doi: 10.2217/fon-2020-1112. Epub 2021 Feb 23.
We aim to provide new insights into the mechanisms of hepatocellular carcinoma (HCC) and identify key genes as biomarkers for the prognosis of HCC. Differentially expressed genes between HCC tissues and normal tissues were identified via the Gene Expression Omnibus tool. The top ten hub genes screened by the degree of the protein nodes in the protein-protein interaction network also showed significant associations with overall survival in HCC patients. A prognostic model containing a five-gene signature was constructed to predict the prognosis of HCC via multivariate Cox regression analysis. This study identified a novel five-gene signature (, , , and ) as a significant independent prognostic factor.
我们旨在深入了解肝细胞癌（HCC）的发病机制，并确定关键基因作为 HCC 预后的生物标志物。通过基因表达综合数据库工具鉴定 HCC 组织与正常组织之间的差异表达基因。通过蛋白质-蛋白质相互作用网络中蛋白节点的程度筛选出的前 10 个枢纽基因，在 HCC 患者的总生存中也表现出显著相关性。通过多变量 Cox 回归分析构建包含 5 个基因特征的预后模型，以预测 HCC 的预后。本研究确定了一个新的 5 个基因特征（、、、和）作为显著的独立预后因素。
