Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Transbound Emerg Dis. 2021 Nov;68(6):3103-3106. doi: 10.1111/tbed.14045. Epub 2021 Mar 5.
SARS-CoV-2 RT-PCR cycle threshold values from 18,803 cases (2 March-4 October) in Madrid define three stages: (i) initial ten weeks with sustained reduction in viral load (Ct: 23.4-32.3), (ii) stability with low viral loads (Ct: 31.9-35.5) in the next nine weeks and (iii) sudden increase with progressive higher viral loads until reaching stability at high levels in the next twelve weeks, coinciding with an increased percentage of positive cases and reduced median age. These data indicate differential virological/epidemiological patterns between the first and second COVID-19 waves in Madrid.
马德里 18803 例病例（2020 年 3 月 2 日至 10 月 4 日）的 SARS-CoV-2 RT-PCR 循环阈值数值定义了三个阶段：（i）最初的十周内病毒载量持续下降（Ct 值：23.4-32.3），（ii）接下来的九周内病毒载量保持稳定（Ct 值：31.9-35.5），（iii）随后突然增加，病毒载量逐渐升高，直到接下来的十二周达到高水平的稳定，同时阳性病例的百分比增加，中位年龄降低。这些数据表明马德里的第一波和第二波 COVID-19 之间存在不同的病毒学/流行病学模式。
