Van Geel Fanny, Hvid Lars G, Van Noten Pieter, Eijnde Bert O, Dalgas Ulrik, Feys Peter
REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Belgium; UMSC, Hasselt-Pelt, Belgium.
Exercise Biology, Department of Public Health, Aarhus University, Denmark.
Mult Scler Relat Disord. 2021 May;50:102841. doi: 10.1016/j.msard.2021.102841. Epub 2021 Feb 10.
Both muscle fatigability and walking fatigability are prevalent in persons with MS (pwMS), but their associations remains unclear. The aim of this study was to examine the association of muscle strength and fatigability from both isometric and concentric protocols of three different muscle groups, and their association to walking capacity and walking fatigability.
Twenty-seven pwMS and 13 Healthy Controls (HC) were included in this exploratory study. All participants performed a six-minute walking test (6MWT), where the distance walked index (DWI) was calculated to measure walking fatigability with a cut-off score of -10%. In three different muscle groups (knee extensors (KE), knee flexors (KF), ankle dorsiflexors (DF)), isometric and concentric muscle fatigability protocols (FI or FI) were used to quantify maximal voluntary contraction (MVC) and muscle fatigability. Pearson or Spearman correlation coefficients and linear regression models were calculated to establish the association between muscle strength/fatigability and walking capacity/fatigability.
Higher MVCs values for all muscle groups were found in HC compared to pwMS (mainly those having walking fatigability) (p < 0.05). FI of DF was lower in pwMS having walking fatigability compared to no walking fatigability. MVC of KE, KF and DF had a low to moderate association with walking capacity (range r = 0.52-0.56; p < 0.05) and walking fatigability in pwMS (range r-r: 0.39-0.50; p<0.05). FI of KF and DF, but not of KE, were associated with walking fatigability (r = 0.39 and r = 0.47, respectively; p < 0.05). In contrast, FI for all muscle groups were not related to walking capacity or walking fatigability.
MVC of KE, KF and DF are associated with walking capacity and walking fatigability, while concentric (but not isometric) muscle fatigability of KF and DF are associated with walking fatigability.
肌肉疲劳性和行走疲劳性在多发性硬化症患者（pwMS）中都很常见，但它们之间的关联尚不清楚。本研究的目的是通过三种不同肌肉群的等长和向心收缩方案来研究肌肉力量与疲劳性之间的关联，以及它们与行走能力和行走疲劳性的关联。
本探索性研究纳入了27名pwMS患者和13名健康对照者（HC）。所有参与者都进行了六分钟步行测试（6MWT），计算行走距离指数（DWI）以测量行走疲劳性，临界值为-10%。在三个不同的肌肉群（膝伸肌（KE）、膝屈肌（KF）、踝背屈肌（DF））中，使用等长和向心肌肉疲劳性方案（FI或FI）来量化最大自主收缩（MVC）和肌肉疲劳性。计算Pearson或Spearman相关系数以及线性回归模型，以建立肌肉力量/疲劳性与行走能力/疲劳性之间的关联。
与pwMS患者（主要是那些有行走疲劳性的患者）相比，HC中所有肌肉群的MVC值更高（p < 0.05）。与没有行走疲劳性的pwMS患者相比，有行走疲劳性的pwMS患者的DF的FI更低。KE、KF和DF的MVC与pwMS患者的行走能力（范围r = 0.52 - 0.56；p < 0.05）和行走疲劳性（范围r - r：0.39 - 0.50；p < 0.）有低到中度的关联。KF和DF的FI（但KE的FI除外）与行走疲劳性相关（分别为r = 0.39和r = 0.47；p < 0.05）。相比之下，所有肌肉群的FI与行走能力或行走疲劳性均无关联。
KE、KF和DF的MVC与行走能力和行走疲劳性相关，而KF和DF的向心（而非等长）肌肉疲劳性与行走疲劳性相关。
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