Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany;
Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.
In Vivo. 2021 Mar-Apr;35(2):947-953. doi: 10.21873/invivo.12335.
The aim of this case report was to detail diagnosis and therapy in a case of implant-associated peripheral giant cell granuloma (IA-PGCG) of the jaw. Case Report: The 41-year-old female attended the outpatient clinic for treatment of recurrent mandibular IA-PGCG. The lesion was excised and the defect was closed with a connective tissue graft of the palate. Healing of oral defects was uneventful, and no local recurrence has occurred during a follow-up of 7 months. Genetic examination of the lesion identified a somatic mutation in KRAS. Conclusion: The lesions are assessed as reactive-inflammatory changes in the mucous membrane of the oral cavity. The cause of the lesion is unknown. KRAS mutations are commonly found in various cancer tissues, but also in germline and mosaic RASopathies. Recently, KRAS mutations have been identified in several IA-PGCG. The clinical course of a frequently locally recurring lesion gives rise to the assumption that lesions of this type show characteristics known in benign neoplasms.
本病例报告旨在详细介绍一例颌骨种植体相关外周巨细胞肉芽肿(IA-PGCG)的诊断和治疗。
一名 41 岁女性因复发性下颌 IA-PGCG 就诊于门诊。病变被切除,并用腭部的结缔组织移植物封闭缺损。口腔缺损愈合顺利,随访 7 个月无局部复发。病变的基因检测发现 KRAS 体细胞突变。
病变被评估为口腔黏膜的反应性炎症性改变。病变的原因尚不清楚。KRAS 突变常见于各种癌症组织,但也存在于种系和嵌合 RAS 病中。最近,在几种 IA-PGCG 中发现了 KRAS 突变。频繁局部复发的病变的临床过程提示此类病变具有良性肿瘤的特征。