细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）基因多态性（rs3087243）与结直肠癌患者的风险和生存相关。

Cytotoxic T-lymphocyte Antigen-4 () Gene Polymorphism (rs3087243) Is Related to Risk and Survival in Patients With Colorectal Cancer.

机构信息

Department of Medical Laboratory, Danang University of Medical Technology and Pharmacy, Danang, Vietnam.

Department of Laboratory Medicine and Pathology, Region Jönköping County, Jönköping, Sweden.

出版信息

In Vivo. 2021 Mar-Apr;35(2):969-975. doi: 10.21873/invivo.12339.

DOI:10.21873/invivo.12339

PMID:33622891

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8045117/

Abstract

BACKGROUND/AIM: Cytotoxic T-lymphocyte antigen-4 (CTLA-4), transiently expressed on T cells, plays a pivotal role in the negative feedback regulation of T-cell activation and proliferation. The aim of the present study was to examine the influence of CTLA-4 gene polymorphism rs3087243 on CRC susceptibility and long-term survival in Swedish patients with CRC.

PATIENTS AND METHODS

Genotypes of 491 patients and 433 healthy controls were determined, using TaqMan single nucleotide polymorphism (SNP) assays based on polymerase chain reaction.

RESULTS

Patients carrying allele A were found to be at a higher risk of CRC and this allele was found to be more common in patients with disseminated disease compared to localized disease in the right colon. Kaplan-Meier analysis of cancer-specific survival showed that carriers of allele A had the highest risk of CRC-related death.

CONCLUSION

The SNP rs3087243 of the CTLA-4 gene was associated with CRC risk and, therefore, it could be a prognostic marker for Swedish patients with CRC.

摘要

背景/目的：细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）在 T 细胞上短暂表达，在 T 细胞激活和增殖的负反馈调节中发挥关键作用。本研究旨在探讨 CTLA-4 基因多态性 rs3087243 对瑞典结直肠癌（CRC）患者易感性和长期生存的影响。

患者和方法

采用基于聚合酶链反应的 TaqMan 单核苷酸多态性（SNP）检测方法，对 491 例患者和 433 例健康对照者的基因型进行了检测。

结果

携带等位基因 A 的患者患 CRC 的风险较高，并且该等位基因在右结肠癌中弥散性疾病患者中比局限性疾病患者更为常见。癌症特异性生存的 Kaplan-Meier 分析显示，携带等位基因 A 的患者 CRC 相关死亡的风险最高。

结论

CTLA-4 基因的 SNP rs3087243 与 CRC 风险相关，因此可能是瑞典 CRC 患者的预后标志物。

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细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）基因多态性（rs3087243）与结直肠癌患者的风险和生存相关。

Cytotoxic T-lymphocyte Antigen-4 () Gene Polymorphism (rs3087243) Is Related to Risk and Survival in Patients With Colorectal Cancer.

机构信息

Department of Medical Laboratory, Danang University of Medical Technology and Pharmacy, Danang, Vietnam.

Department of Laboratory Medicine and Pathology, Region Jönköping County, Jönköping, Sweden.

出版信息

In Vivo. 2021 Mar-Apr;35(2):969-975. doi: 10.21873/invivo.12339.

DOI:10.21873/invivo.12339

PMID:33622891

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8045117/

Abstract

PATIENTS AND METHODS

Genotypes of 491 patients and 433 healthy controls were determined, using TaqMan single nucleotide polymorphism (SNP) assays based on polymerase chain reaction.

RESULTS

CONCLUSION

The SNP rs3087243 of the CTLA-4 gene was associated with CRC risk and, therefore, it could be a prognostic marker for Swedish patients with CRC.

摘要

患者和方法

采用基于聚合酶链反应的 TaqMan 单核苷酸多态性（SNP）检测方法，对 491 例患者和 433 例健康对照者的基因型进行了检测。

结果

结论

CTLA-4 基因的 SNP rs3087243 与 CRC 风险相关，因此可能是瑞典 CRC 患者的预后标志物。

细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）基因多态性（rs3087243）与结直肠癌患者的风险和生存相关。

Cytotoxic T-lymphocyte Antigen-4 () Gene Polymorphism (rs3087243) Is Related to Risk and Survival in Patients With Colorectal Cancer.

机构信息

出版信息

PATIENTS AND METHODS

RESULTS

CONCLUSION

患者和方法

结果

结论

相似文献

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细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）基因多态性（rs3087243）与结直肠癌患者的风险和生存相关。

Cytotoxic T-lymphocyte Antigen-4 () Gene Polymorphism (rs3087243) Is Related to Risk and Survival in Patients With Colorectal Cancer.

机构信息

出版信息

PATIENTS AND METHODS

RESULTS

CONCLUSION

患者和方法

结果

结论