根治性膀胱切除术后晚期膀胱癌患者的控制营养状况（CONUT）评分。
The Controlling Nutritional Status CONUT Score in Patients With Advanced Bladder Cancer After Radical Cystectomy.
机构信息
Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
Department of Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan
出版信息
In Vivo. 2021 Mar-Apr;35(2):999-1006. doi: 10.21873/invivo.12343.
Abstract
BACKGROUND/AIM: The impact of the controlling nutritional status (CONUT) score on oncological outcomes after radical cystectomy (RC) for advanced bladder cancer (BC) is unknown.
PATIENTS AND METHODS
We retrospectively evaluated 115 patients who underwent RC for advanced BC at our department between November 2003 and February 2019. The CONUT score was calculated from serum albumin levels, total lymphocyte counts, and total cholesterol levels. Relapse-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) after RC were analyzed.
RESULTS
For the CONUT score, the area under curve was 0.651 and the optimal cut-off value determined using the Youden index was 3. The high CONUT group had significantly shorter RFS, CSS, and OS than the low CONUT group. Multivariate analyses showed that the CONUT score was an independent prognostic factor of RFS, CSS, and OS.
CONCLUSION
The CONUT score could be an effective predictor for survival and tolerability following RC for advanced BC.
摘要
背景/目的：控制营养状态（CONUT）评分对接受根治性膀胱切除术（RC）治疗晚期膀胱癌（BC）患者的肿瘤学结局的影响尚不清楚。
患者和方法
我们回顾性评估了 2003 年 11 月至 2019 年 2 月在我科接受 RC 治疗的 115 例晚期 BC 患者。CONUT 评分通过血清白蛋白水平、总淋巴细胞计数和总胆固醇水平计算得出。分析 RC 后的无复发生存（RFS）、癌症特异性生存（CSS）和总体生存（OS）。
结果
对于 CONUT 评分，曲线下面积为 0.651，使用约登指数确定的最佳截断值为 3。高 CONUT 组的 RFS、CSS 和 OS 明显短于低 CONUT 组。多变量分析显示，CONUT 评分是 RFS、CSS 和 OS 的独立预后因素。
结论
CONUT 评分可能是预测接受 RC 治疗的晚期 BC 患者生存和耐受性的有效指标。
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