McCafferty J A, Lang S D
Department of Clinical Microbiology, Middlemore Hospital, Otahuhu, Auckland.
N Z Med J. 1988 Apr 27;101(844):210-1.
An audit of the use of antibiotics restricted by the hospital formulary was undertaken by retrospective analysis of 73 written justifications for prescriptions provided to the pharmacy and the case notes. Half of the prescriptions were for therapeutic indications with the remainder divided almost equally between prophylactic and empirical use. The cost of therapy was $34,500. Antibiotic use was classified as appropriate or inappropriate. Inappropriate use was seen in 22 cases at an excess cost of $3828. Prophylactic use accounted for 13 of the inappropriate prescriptions, most frequently due to excessive duration of prescription. The use of amikacin where gentamicin was not contraindicated was seen in 4 of 9 inappropriate prescriptions. The infrequent use of the more expensive antibiotics and the potentially remediable inappropriate use seen with prophylaxis were gratifying aspects of this audit.
通过对提供给药房的73份处方书面理由及病历进行回顾性分析，对医院处方集限制使用的抗生素使用情况进行了审核。一半的处方用于治疗指征，其余的几乎平均分为预防性使用和经验性使用。治疗费用为34,500美元。抗生素使用被分类为适当或不适当。22例出现不适当使用，额外费用为3828美元。预防性使用占13份不适当处方，最常见的原因是处方时间过长。在9份不适当处方中有4份在庆大霉素无禁忌的情况下使用了阿米卡星。较昂贵抗生素的使用频率较低以及预防性使用中出现的潜在可纠正的不适当使用是本次审核中令人欣慰的方面。
